Associate Principal Scientist –PeptideDevelopmentChemistry - Pharmaceutical Sciences; PS

Associate Principal Scientist – Peptide Development Chemistry - Pharmaceutical Sciences (PS)

Location:

Macclesfield, UK

AstraZeneca is a global, science‑led, patient‑focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death.

We’ll strengthen our pharmaceutical sciences capability through the role of Associate Principal Scientist – Peptide Development Chemistry on constructive challenge. Working in the Early Chemical Development (ECD) New Modalities team we will manage peptide and peptide‑conjugate projects and help bring peptide‑based products to market.

• Act as project technical lead for early chemical development of complex peptide and peptide‑conjugate drug projects, driving process development and manufacturing of peptide‑containing drug substances and defining manufacturing strategy for API processes, primarily through external partnership with CMDOs.
• Demonstrate scientific leadership, contribute strategic thinking and provide expert challenge within peptide (and peptide‑conjugate) drug project CMC teams, role‑modeling positive behaviours in new ways of working and accelerating scientific development.
• Engage outward‑facing perspective to identify opportunities, collaborate across functional and departmental boundaries, tap into specialist capabilities and external expertise.
• Mentor and develop colleagues, supporting them in reaching their full potential.
• Enhance AstraZeneca’s scientific reputation through publishing research and engaging in external collaborations.

• Degree or equivalent scientific qualification (Master’s or PhD preferred) in a relevant field.
• Deep understanding of the drug development process, spanning discovery through to launch, with clear evidence of significant CMC project expertise.
• Significant direct experience of peptide‑specific chemical development with a track record of delivery and creativity in leading drug substance development projects within a CMC organisation, with demonstrated skill to provide influence, strategic direction, deliver technical supervision (internally/externally) and give mentorship.
• Hands‑on experience of conjugation chemistry involving peptide linkers or peptide targeting agents.
• Solid understanding of the regulatory environment for clinical development and supply of peptide and peptide‑containing drug substance.

• Strong leadership skills, excellent communication and strategic influencing ability, including experience of partnering with external CROs and CDMOs.
• Strong development focus of self and others, with an interest in learning about new scientific areas.
• Ability to think and operate across functional boundaries, challenge the status‑quo and seek opportunities for business improvement.

We encourage in‑office collaboration, with a minimum of four days per week in the office, while offering flexibility to support individual needs.

The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, performance recognition scheme and a competitive, generous remuneration package.

Our mission is to build an inclusive and equitable environment. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments and accommodations. If you need adjustments, complete the section in the application form.