Senior Scientist – Asymmetric Catalysis and -Throughput Experimentation

Senior Scientist – Asymmetric Catalysis and High-Throughput Experimentation

AstraZeneca is a global biopharmaceutical company focused on innovating and delivering life-saving medicines while prioritizing sustainability and minimizing our environmental impact. We foster a collaborative, inclusive culture where colleagues are empowered to share ideas and feel valued and rewarded.

Pharmaceutical Technology & Development (PT&D) transforms cutting-edge science into medicines for millions, working across the value chain to design, develop, and scale up drug products from early research through commercial manufacture.

In Chemical Development, we combine scientific expertise and innovation to create and optimize sustainable, commercially viable processes for active pharmaceutical ingredients. By collaborating widely and embracing new technologies, we continually improve how we deliver medicines.

Catalysis and High-Throughput Experimentation (HTE) facilitate the development of efficient and sustainable processes, allowing innovative routes to API (Active Pharmaceutical Ingredient) molecules that are increasing in complexity. The catalysis and HTE group support the development and manufacture of drug projects across the portfolio, from late-discovery to launch, with key expertise in a range of technologies such as cross-coupling, asymmetric reactions, and the use of gases in synthesis.

We are offering an exciting Senior Scientist position in asymmetric catalysis and HTE in our vibrant team, with the successful candidate joining a cutting-edge pharmaceutical lab with access to glove boxes and state of the art HTE equipment. The responsibilities and requirements of the position are outlined below.

The role is based at the Macclesfield Campus, Cheshire.

• Lab based role involving the design and execution of catalytic reactions with the ability to interpret data, analyse results and plan the next steps accordingly.

• Has a good understanding of reactions relevant to the pharmaceutical industry and an up-to-date knowledge of the literature in relevant areas of asymmetric catalysis and synthesis.

• Seeks out the most appropriate methods for carrying out experimental work to a high standard utilizing high-pressure equipment, high-throughput experimentation and automation where appropriate.

• Collaborates with other members of the catalysis team, drug project teams or external academic collaborators to contribute to the development of new medicines.

• A PhD aligned to organic synthesis and/or catalysis, or BSc/MSc with relevant industrial experience to an equivalent level.

• Experience in high-throughput experimentation (HTE) and running pressure reactions, with a strong understanding of safe laboratory practices and relevant experimental procedures.

• An excellent understanding of synthetic reagents and methodologies, reaction mechanisms and modern analytical techniques.

• A record of scientific innovation, through publication authorship, patent inventorship, or conference presentation.

• The ability to work effectively within a team environment.

• Lab-based pharmaceutical industry and/or process development experience with awareness of considerations for design of synthetic routes for scale-up and manufacture of APIs.

• The confidence to coach and drive performance and development among your peers.

• Excellent communication skills, with the ability to communicate across interfaces of scientific disciplines, culture, and expertise both internally and externally.

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