Associate Principal Scientist

We are currently recruiting for a Associate Principal Scientist, HT-Analytical Method Development to join our Analytical Sciences team based in Alderley Park.

Role: Associate Principal Scientist (High Throughput ADME Method Development)

Role Type: Permanent

Department
:
Analytical Sciences

Responsible for: Junior team members, as may be assigned

Working hours: Full time, 9am-5pm, Monday - Friday (37.5 hours per week)

Location: Alderley Park, Macclesfield, SK10 4TG

Cyprotex is part of the Evotec Group, a global leader in research. With state-of-the-art facilities and technical expertise, we provide innovative and bespoke assurance tailored to each of our client’s needs. Cyprotex specialises in in-vitro and in-silico ADME-Tox services. This includes in vitro ADME screening to support discovery projects, regulatory in vitro ADME and DDI studies during preclinical and clinical development, specialist mechanistic in vitro human and animal toxicity models (e.g., 3D models and MEA electrophysiology) and PBPK/QSAR modelling expertise.

As well as supporting clients directly, we have a strong focus on R&D.

Our Alderley Park site is set in the heart of Cheshire surrounded by a stunning 400-acre estate, open green spaces, and sweeping viewpoints, all within easy reach of Merseyside and Greater Manchester, Staffordshire, Derbyshire and Shropshire. Easy access to public transport.

As a result of year-on-year success within the company and continued business growth, an exciting opportunity has arisen to join our team of highly skilled scientists in our High-Throughput Analytical laboratories.

• Plan and conduct Method Development projects (using LC-MS or LC-MS/MS) for non standard client compounds (including difficult small molecules and diverse chemical modalities) that are proposed to run through a range of ADME assays
• Perform and document fit for purpose method qualification studies for relevant regulatory DDI projects
• To be a senior point of contact both internally and externally, for project related communication on a range of assigned method development projects,
• To collaborate with scientists from beyond the Analytical team in order to understand the context of application of methods
• Ensure that all errors and erroneous results are reported and corrected with minimal delay.
• To keep up to date with relevant scientific advances and regulatory guidelines in the field of Analytical Sciences.
• Ensure all laboratory equipment and work areas are kept clean and in proper working order on completion of assigned tasks.
• To ensure accurate and complete documentation of all activities as required by relevant SOPs and Quality policies.
• To keep up to date with future technologies/instrumentation establishing benefits and implementation for HT-Analytical Method Development
• As a Senior member of the Analytical team influence the direction and investment in analytical capabilities.

• Minimum BSc in relevant scientific discipline covering chemistry with experience of working within industry
• Extensive experience of developing robust bioanalytical methods using relevant compound handling, sample preparation and LC-MS workflows.
• Produce accurate documentation and report all method development activities and results in a clear and coherent manner, maintaining the highest standards of quality and compliance, with a high level of attention to detail and the ability to work without close supervision.
• Highly motivated team player with a high level of dedication.
• Plan, schedule and carry out your work effectively for successful project completion to tight deadlines.
• Experience in working with LC-MS/MS techniques in support of pre-clinical small/large molecule assays.
• Experience…