Product Manager - Upstream

Organ Ox is a commercial stage organ technology company dedicated to developing technologies to improve outcomes for patients with acute or chronic organ failure. The company was established as a spin out of the University of Oxford in 2008 and is now part of the Terumo Group. Organ Ox is a pioneer in normothermic machine perfusion (NMP). It's flagship platform, the metra®, is available for use in the U.S., Europe, Canada, and Australia.

It has been utilized in over 7,000 liver transplants to date to keep donor livers in a metabolically active state outside the body enabling longer preservation times and functional assessment of the organ prior to transplant, leading to an increased number of organs available for transplant. Founded in 1921, Terumo Corporation (TSE:4543) strives to fulfill its mission of “Contributing to Society through Healthcare” by providing a comprehensive range of solutions in the fields of therapeutic procedures, hospital operations, and life sciences in more than 160 countries and regions.

Organ Ox has an exciting career opportunity for a Product Manager, Upstream at our global headquarters in Oxford, UK. In this role you will oversee full lifecycle management for our existing product portfolio with primary focus on early-stage innovation, strategic planning, and foundational requirements for our next-generation, connected medical device portfolio. You will act as the ultimate voice of the customer, bridging the gap between clinical needs and technical development.

This role focuses on the  front end  of innovation—identifying high-value clinical opportunities, building business cases, and defining product requirements before handing off to downstream teams for commercial launch. You will report to the Global Director of Marketing.

Under direction from the Director, Marketing the Product Manager, Upstream will be responsible for:

• Own and define the 1.5-to-5-year global product roadmap for your assigned clinical portfolio, ensuring alignment with corporate growth targets.
• Lead strategic portfolio prioritization exercises, balancing disruptive innovation with incremental product line extensions.
• Monitor changing healthcare regulations, policies governing organ donation and use, global macroeconomic healthcare trends, clinical literature, reimbursement shifts, and competitive intelligence to pivot strategy proactively.

• Design and execute comprehensive global Voice of Customer (VOC) strategies, including advisory boards, primary and secondary research, and procedural observations.
• Partner with Key Opinion Leaders (KOLs), medical advisory boards, and scientific communities to identify high-value unaddressed clinical needs.
• Analyze international healthcare economics to integrate global pricing, reimbursement, and market-access requirements early in the product concept phase.

• Author rigorous, executive-level business cases complete with complex financial models, target pricing, net present value (NPV) analytics, and risk assessments.
• Drive funding approval through corporate Stage-Gate governance reviews by defending market assumptions and return on investment (ROI) metrics.
• Partner with head of business development to provide commercial due diligence for external partnership, licensing, or acquisition (BD&L) opportunities.

• Translate ambiguous clinical insights into precise, high-level Product Requirements Documents (PRDs) and system-level design inputs.
• Represent the “commercial voice” in cross-functional core teams consisting of senior leaders from R&D, Clinical…