Associate Scientist , Scale Synthesis

Associate Scientist I, Small Scale Synthesis

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein.

Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing to address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Our corporate headquarters is in Pasadena, CA, with research and development teams in Madison, WI & San Diego, CA, and a state‑of‑the‑art manufacturing facility in Verona, WI. Our employees are nimble, science‑driven innovators collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking an Associate Scientist I to join the Discovery Chemistry Department. The successful candidate will primarily focus on oligonucleotide synthesis, purification, analytical chemistry, and contributing to specific program goals. The Associate Scientist will be joining a team of highly motivated and experienced scientists and will contribute to the success of Arrowhead programs.

Responsibilities

• Maintain a well‑documented laboratory notebook.
• Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
• Manage time effectively to meet deadlines.
• Adhere to safe laboratory practices.
• Perform synthesis, purification, and analysis of oligonucleotides.
• Assist with maintenance of bioconjugate and oligonucleotide inventory.

Requirements

• B.S. in Chemistry or Biochemistry with an excellent understanding of organic and analytical chemistry.
• 0‑2 years of experience working in a chemistry laboratory.
• Experience with a wide range of analytical techniques, especially HPLC.
• Ability to quickly learn new procedures and techniques.

Preferred

• Experience working with large molecule synthetic targets (especially oligonucleotides) either in an academic or industry setting.
• Previous experience working in a pharmaceutical setting.

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

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