Executive Director, Oncology Early Clinical Development Lead

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting‑edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success.

We’re uniting science, technology, and talent to get ahead of disease together.

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Our approach to R&D

GSK Oncology Clinical Development is seeking a highly skilled and motivated Executive Director, Oncology Early Clinical Development Lead to join our dynamic Oncology Research and Development team. In this role the successful candidate will create a strong link between Clinical Development and Pre‑clinical/ Discovery teams to improve forward and reverse translation and, thereby, increase the success of our Oncology clinical portfolio.

They will be responsible for leading a team of talented Oncology Early Clinical Development Medical Directors and Clinical Scientists who will design and execute early‑phase clinical studies, as well as contribute to the translational research strategy for early phase clinical assets. This role offers a unique opportunity to bridge the gap between preclinical research and clinical development, ensuring the successful translation of innovative therapies from the lab to the clinic.

Please note:

This position requires an on‑site office‑based presence 2 to 3 days a week in the US (Upper Providence, PA. or Waltham, MA.); UK (London or Stevenage);
Switzerland (Zug) or Poland (Warsaw).

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Accountable for the clinical development plans (CDPs) for a portfolio of early phase (Phase I/II) clinical study protocols, including first‑in‑human (FIH) trials, dose‑escalation studies, and proof‑of‑concept (POC) studies.
• Accountable for overall benefit: risk of a clinical program. If not a physician, the CDL is expected to delegate to and interface closely with the appropriate physician(s) on the program.
• Accountable for driving the end‑to‑end clinical development strategy and alignment to target medicine profiles (TMP) and integrated evidence plans (IEP), spanning all phases of development, including trial design, execution, and interpretation and delivery of trial results.
• Lead clinical development discussions and teams at regulatory interactions and accountable for drafting clinical components of regulatory submissions/files (i.e. IND, NDA, BLA, MAA) including briefing documents, presentations, addressing questions and responses.
• Participate as a core member of the Medicine Development Team (MDT) or Early Development Team (EDT) and provide a single Clinical Development accountability at the program level within these teams and other cross‑functional partnerships with Medical Affairs, Integrated Evidence, Publications, and Global and Regional Commercial functions.
• Ensure that all clinical studies are conducted in compliance with applicable regulatory requirements, Good Clinical Practice (GCP) guidelines, and GSK policies and procedures.
• Lead the cross‑functional Clinical Matrix Team and provide clinical leadership, Oncology Clinical Development expertise, and customer insight for the program.

• Oversee the development and execution of the clinical development components of the overall translational science strategy in partnership with Oncology Early Development Leaders, Oncology Translational Science, pre‑clinical Oncology Research teams (ETCT & ITCT), AI/ML, Clinical Pharmacology & Experimental Medicine, Research Technologies.
• Partner with the Oncology Tumor Teams (OTTs) to develop the translational strategy across assets within a given tumor and drive OTT activities with a clinical and…