Sr. Research Investigator

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.

As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America’s Best Large Employers in 2023.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Sr. Research Investigator

Research Investigator, Senior

The Armellino Center of Excellence for Williams Syndrome at Penn and CHOP is seeking a Senior Research Investigator, who will initiate, contribute and manage development of multiple research projects and study protocols of Dr. Mark Levin. Dr. Levin's studies are focused on cardiovascular manifestation of Williams syndrome, with specific emphasis on sudden cardiac death. Selected candidate will be leading the animal studies, conducting electrophysiology experiments, including those requiring experience with patch clamp technique.

To ensure success of all researches/clinical studies, Senior Research Investigator will work with Principal Investigator, Dr. Mark Levin, and will closely interact with post doctoral fellows and students in the laboratory, as well as will participate in developing and following safety procedures and research SOPs and protocols for general laboratory practices, in compliance with safety regulations. It is anticipated that Senior Research Investigator will assist with preparation of conference presentations and with preparation of drafts of manuscripts to submitted to peer-reviewed journals.

The Senior Research Investigator will initiate, contribute and manage development of multiple research projects and study protocols of Dr. Mark Levin. Dr. Levin's studies are focused on cardiovascular manifestation of Williams syndrome, with specific emphasis on sudden cardiac death. Selected candidate will be leading the animal studies, including whole animal, organ level and isolated cardiomyocyte electrophysiology experiments. These include in vivo cardiac electrophysiology testing, optical mapping with voltage and calcium sensitive dyes and isolated cardiomyocyte studies using whole cell patch clamp, mycoyte contractility and calcium imaging techniques.

To ensure success of all researches/clinical studies, Senior Research Investigator will work with Principal Investigator, Dr. Mark Levin, and will closely interact with postdoctoral fellows and students in the laboratory, as well as will participate in developing and following safety procedures and research SOPs and protocols for general laboratory practices, in compliance with safety regulations. It is anticipated that Senior Research Investigator will assist with preparation of conference presentations and with preparation of drafts of manuscripts to submitted to peer-reviewed journals.

Desired individual will both plan experiments, troubleshoot commonly occurring problems and should be able to interpret data quality and results.

• Experimental design
• Conducting experiments at the bench
• Conducting animal experiments
• Data analysis
• Preparing manuscripts
• Presenting data at conferences and appropriate professional meetings
• Perform additional duties as assigned

** Contingent upon funding**

• Doctor of Medicine, Doctor of Philosophy, and 5 to 7 years of post doc experience is required.
• Expertise in designing and carrying out cellular and whole animal elcetrophysiology experiments involving optical mapping with voltage sensitive dyes, isolating ventricular myocytes from murine models for use in whole-cell patch clamp studies and calcium transient recordings and in vivo mouse cardiac electrical studies using programmed electrical stimulation. PREFERRED

Philadelphia, Pennsylvania

Perelman School of Medicine

$79,500.00 - $ Annual Rate

Salary offers are made based on the candidate’s qualifications,…