Senior Analytical Multi-omics Team Lead​/Manager

Overview

The Advanced Regenerative Manufacturing Institute (ARMi)
IBioFabUSA is a Member-based non-profit organization founded to build the biofabrication industry and transform the future of healthcare. ARMI provides wrap-around commercialization services to companies seeking to bring life-saving regenerative technologies to patients, as well as to innovators seeking to commercialize enabling technologies that will grow the industry's impact.

ARMI is seeking an experienced scientist to lead our analytical multi-omics group. The successful candidate will be responsible for overseeing daily operations of a core facility that ensures the generation of high-quality, reliable data to support process development for cell-based therapy manufacturing. The individual will lead a small team of scientists and technicians, maintain instrumentation, drive continuous improvement and safety and, as needed, will ensure regulatory compliance.

This role requires particularly strong technical expertise in chromatography principles, mass spectrometry and method validation protocols supporting untargeted and targeted metabolomics, proteomics and lipidomics. The ideal candidate would also oversee method development, validation and routine analysis for techniques such as HPLC, GC, FTIR and UV-Vis spectrophotometry.

• Lead and mentor analytical scientists and technicians
• Schedule and prioritize analytical projects to meet organizational and client deadlines
• Collaborate with cross-functional teams including process development, data science, quality, and regulatory affairs
• Present findings and recommendations to internal stakeholders and external clients
• Manage multiple projects simultaneously while meeting critical timelines and deliverables
• Support regulatory submissions and client audits as needed

• Develop and validate robust LC-MS/MS methods for lipids, proteins, and metabolites, and methods for gene expression profiling, in a variety of cell types and in culture matrices that may include animal serum
• Optimize sample preparation procedures, chromatographic conditions and mass spectrometer parameters to achieve required sensitivity, selectivity, and throughput
• Troubleshoot analytical challenges and implement innovative solutions to overcome matrix effects and interference issues

• Conduct method transfers and technology transfers between laboratories and instruments
• Prepare standard operating procedures, technical documentation and detailed validation reports
• Maintain compliance, as needed and in collaboration with Quality Assurance staff, with GLPs, GMPs, and other applicable quality standards

• Operate and maintain equipment including troubleshooting, routine calibration and preventative maintenance
• Collaborate with service engineers and vendors for instrument optimization and upgrades
• Train laboratory personnel on proper instrument operation and safety procedures

• Exceptional interpersonal, written and verbal communication skills
• Experience working in a fast-paced, dynamic, collaborative team environment
• High energy, commitment, initiative, and perseverance

• Bachelor's degree in Chemistry, Analytical Chemistry, Biochemistry, or related field with 15-20 years of relevant experience, or Master's degree with 10-15 years of relevant experience, or PhD with 5-10 years of relevant experience
• Demonstrated hands-on experience with LC-MS/MS method development and validation in regulated environments

• Proficiency with major LC-MS/MS and untargeted and targeted gene expression platforms
• Strong understanding of mass spectrometry principles, ionization techniques, and fragmentation patterns
• Experience with various chromatographic techniques, including specialty columns
• Knowledge of sample preparation techniques for small molecules, lipids, proteins and nucleic acids
• Familiarity with data acquisition and processing software
• Knowledge of LC-MS/MS applications in process development, preclinical research, and clinical research
• Strong…