Research Associate, Research Scientist

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Manchester Cell Matrix Centre & Discovery Research Platform for Cell-Matrix Biology

The Manchester Cell Matrix Centre (MCMC) brings together diverse research groups and technologists whose collective efforts are focussed on understanding the body’s extracellular matrix. The extracellular matrix is a complex network that is essential for multicellular life, surrounds and supports cells and accounts for one third of our body mass. We believe that defining the principles that govern the two-way interaction between cells and matrix is fundamental to understanding vertebrate development, healthy ageing, and identifying why tissue failure is a major factor in most chronic diseases.

Located at The University of Manchester, the Centre is one of eight Discovery Research Platforms recently awarded by the Wellcome Trust. The Discovery Research Platform for Cell-Matrix Biology will address a range of practical, technological, and methodological barriers to understanding how changes in the extracellular matrix lead to tissue failure. We are seeking driven and ambitious individuals to play a pivotal role in overcoming these barriers.

Successful candidates will contribute to our bold vision to reprogramme extracellular matrix, which has the potential to lead to innovative new diagnostic tools and treatments for diseases such as cancer and fibrosis. The platform will embrace a Team Science approach and provide an exciting opportunity to work with groups from diverse research areas and collaborate across disciplines.

Overall Purpose of the Role

The focus of this role is the composition, organisation and turnover of matrix proteins within normal and diseased tissues. Working with research groups across the Platform and the Biological Mass Spectrometry facility you will develop proteomic and degradomic approaches to understand the matrix changes that occur within tissues across circadian time and through progression of disease, including fibrosis and cancer. The project will involve a range of mass spectrometry based proteomic techniques, including label based (SILAC) and label free quantitative proteomics, proximity labelling (BioID) and degradomic technologies.

Benefits

• Fantastic market leading Pension scheme
• Excellent employee health and wellbeing services including an Employee Assistance Programme
• Exceptional starting annual leave entitlement, plus bank holidays
• Additional paid closure over the Christmas period
• Local and national discounts at a range of major retailers

Equal Opportunities Employer

As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

Working Arrangements

Hybrid working arrangements may be considered. Our University is positive about flexible working – you can find out more here.

Contact Information

Enquiries about the vacancy, shortlisting and interviews:

Name:
Pat Caswell
Email:
Patr

Name:
David Knight
Email: D

General enquiries:

Email:
People.

Technical support:

Application Closure

This vacancy will close for applications at midnight on the closing date.

Additional Information

Please see the link below for the Further Particulars document which contains the person specification criteria.

Seniority level

• Entry level

Employment type

• Full-time

Job function

• Research, Analyst and Information Technology
• Higher Education

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