Scientist – LCMS Analytical

We have an exciting opportunity for a Bioanalytical Scientist with hands-on expertise in LCMS/MS and quantitative PK analysis within a GxP-regulated environment. You be working with complex biological matrices, supporting and developing junior scientists, managing multiple projects and communicating scientific results clearly. Above all, you’re passionate about scientific quality, regulatory compliance and delivering accurate, high-quality data.

We are seeking an experienced bioanalytical scientist with a strong background in LCMS/MS quantitative analysis and pharmacokinetic (PK) studies, ideally with practical experience within a regulated laboratory environment. You will have a BSc, MSc or PhD in Biology, Chemistry or a related scientific discipline, together with a detailed understanding of bioanalytical methodologies and regulatory expectations.

• BSc / MSc/ PhD in Biology/Chemistry (or related scientific discipline) is essential.
• In-depth knowledge of LCMS/MS and experience performing quantitative pharmacokinetic (PK) analysis.
• Comprehensive experience of working in a GxP regulatory laboratory with an understanding of GLP/GCP/GMP principles.
• Specialist Method development and validation experience (ICH M10) for LCMS/MS PK analysis
• Practical knowledge of techniques to extract pharmaceuticals and biopharmaceuticals (small/large molecule) from biological matrices (e.g. serum, plasma and urine).
• You should also be able to demonstrate experience training, supervising and coordinating the work of more junior scientists.
• Good practical laboratory and problem-solving skills.
• Strong numeracy skills with the knowledge of calculating and tabulating results.
• Clear written and verbal communications skills with the ability to clearly convey processes, results and key messages and able to build rapport, quickly and effectively.
• Good interpersonal skills with the ability to collaborate with all areas of the business.
• The ability to effectively time manage personal workload and work on multiple projects as required.
• Good comprehension skills with the ability to interpret analytical information and convert this into a technical report or Certificate of analysis.
• Knowledge and application of appropriate systems and procedures relevant to scientific and analytical methodologies, required regulatory
• standards, research/regulatory procedures and instructions.
• Knowledge and application of safety procedures, laboratory performance standards, handling biological samples, chemicals, COSHH, GMO, SHE and enforcement of safety and quality systems.

The Scientist position is an onsite laboratory-based role within the Operational team. The primary focus is performing LCMS/MS analysis in a GLP, GCP and GMP accredited laboratory. The candidate will have experience of Developing and Validating LCMS/MS methods following ICH M10 guidelines for pharmacokinetic (PK) analysis. The role requires in depth understanding of LCMS/MS and experience of pharmacokinetic (PK) analysis for pharmaceuticals / biopharmaceuticals (for example small molecules, proteins, peptides, lipids and oligonucleotides) in clinical and non-clinical samples.

A Scientist is expected to be an independent member of the lab team and will work across a vast array of projects which will range in scale, scope and timelines.

• In-depth understanding of LC-MS/MS and the application to pharmaceuticals/ bioanalytical analysis.
• Expertise in all practical aspects of quantitative pharmacokinetic (PK) analysis utilising LCMS/MS.
• Provide specialist expertise of method development and validation in accordance with ICH M10 guidelines for quantitative LC-MS/MS PK methods with minimal supervision.
• Experience…