Senior Bioinformatics Research Scientist – Computational Biology and Bioinformatics, Kellogg Lab

Overview

Be at the forefront of the gene editing revolution and contribute to developing next generation therapies for children. Top-tier compensation and benefits, supportive and collaborative team environment with unique opportunities and exciting potential for career advancement.

As part of the Structural Biology Department e Children's Research Hospital,
the Kellogg lab seeks a talented computational biologist who is looking to make high-impact contributions on exciting challenges at the scientific frontier of genome-editing. The Kellogg lab uses cutting edge genetics, cryo-electron microscopy, machine-learning, and protein design to develop novel transposon-based genome-editing tools. Located on the 6th floor of the new Inspiration4 Advanced Research Center (opened in 2021), the Kellogg lab leads the forefront of research in understanding the biology of CRISPR-associated transposons.

The lab is well supported by NIH, Pew Biomedical Foundation, and the Cystic Fibrosis Foundation to develop novel approaches to engineer programmable transposons for clinical gene replacement therapy. The Kellogg lab collaborates with St. Jude core facilities including Cryo-EM Center, the Protein Technology Center, the Single-Molecule Imaging Center, the Center for Advanced Genome Editing, and the Cell & Tissue Imaging Center.

The lab maintains an active presence in Rosetta Commons and the Rosetta community. In this position, the candidate will be exposed to techniques spanning cryo-electron microscopy, computational protein design, machine learning, and advanced genomics in a world-class research environment aimed at advancing cures for genetic disorders.

About you

The successful candidate will be an independent learner with strong critical thinking skills and excellent communication abilities. We seek someone with an outstanding independent track record and stellar academic background who is passionate about research and committed to developing tomorrow's cures for children with devastating genetic disorders. The ideal candidate has extensive experience in one or more of the following: bioinformatic analyses (metagenomic mining is a major plus), reconstructing evolutionary trajectories, mining transposable element databases, etc.

Scientists are expected to operate independently by leading new research directions in the Kellogg lab. The candidate will be mentored in manuscript preparation and provided opportunities for career advancement via conference attendance and oral presentation sponsorship.

• Develop new research directions under close mentorship of Dr. Kellogg.
• Stay up to date with the latest CRISPR and protein engineering literature; conduct regular literature reviews in collaboration with Dr. Kellogg and other Kellogg lab members.
• Collaborate with Kellogg lab members to design & clone large DNA libraries using state-of-the-art machine learning methods.
• Map phylogenetic relationships of CRISPR-associated systems to map functional interactions.
• Develop innovative sequence-profile machine-learning-based protein design pipelines in collaboration with Dr. Kellogg.
• Collaborate with Kellogg lab members to develop novel tools/assays to advance lab research goals.
• Mentor Kellogg lab members in executing internally developed computational analyses and pipelines.
• Prepare manuscripts and present research at relevant conferences, including CRISPR, genome-engineering, or protein design conferences.

• Interdisciplinary scientific research with mentorship in developing leadership skills.
• Opportunities to develop new skills, including experimental biochemistry and/or structure determination in collaboration with Kellogg lab members.
• Attend diverse scientific conferences in computational protein design (including the Rosetta community), machine learning, genome-editing, and transposon biology.
• opportunities for oral presentations at local and national venues and to develop independent research directions.

St. Jude provides compensation commensurate with experience and a comprehensive benefits package. A reasonable estimate of the current salary range is…