Scientist - Protein and Biologics Screening Core; Host-Microbe Interactions

Scientist - Protein and Biologics Screening Core (Host-Microbe Interactions)

Location:

Memphis, TN

Category:
Laboratory Sciences & Support

Department:
Host Microbe Interactions

Shift: Weekday Day

Position Type:
Full Time

Scheduled Weekly

Hours:

40

Station Number: JR5733

Join an excellent team of researchers dedicated to coming closer to the mission of St. Jude Children’s Research Hospital, that no child will die at the dawn of life.

The Protein and Biologics Screening Core within the Department of Host Microbe Interactions e seeks a skilled and highly motivated candidate with experience in Antibody Discovery. This is a unique opportunity to join as an early member of the biologics core where we aim to discover therapeutic molecules to treat unmet pediatric diseases.

Candidates with experience in Hybridoma fusion/B-cell culture are encouraged to apply. A PhD or equivalent is preferred with demonstrated post PhD experience in industry or academia.

• Design and execute antibody discovery campaigns from immunization to lead discovery.
• Utilize immunization, hybridoma/B-cell screening to drive binder discovery.
• Perform high throughput sorting to isolate specific B cell populations.
• Analyze and compare BCR sequences and immune repertoires.
• Serve as project leads for antibody discovery at St Jude.
• Strive for innovation and bring latest technologies to Biologics core.
• Maintain accurate and timely ELN data for discovery campaigns.
• Coordinate external discovery activities.
• Mentoring and help promote an inclusive work culture.

• Extensive knowledge of B-cell immunology and antibody development.
• The ability to design and execute in vivo studies to evaluate antibody efficacy.
• Demonstrated experience with single B-cell antibody discovery approaches. Prior experience with Beacon for mAb discovery would be a plus.
• Hands‑on experience in B-cell sorting and screening through flow cytometry, ELISA and bio‑layer interferometry.
• Experience with antibody‑related bioinformatic/software packages.
• Experience in NGS library preparation and BCR repertoire analysis.
• Experience in high‑throughput cloning of antibody variable domains, antibody expression and characterization techniques (SPR, BLI, epitope binning).

St. Jude Children’s Research Hospital is a world‑class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood. The first and only National Cancer Institute (NCI)‑designated Comprehensive Cancer Center devoted solely to children. Our 300 faculty work across the spectrum of basic, translational, clinical, and population science in a highly collaborative multidisciplinary environment that includes a Nobel laureate and members of the National Academy of Science and the National Academy of Medicine.

St. Jude is ranked on Fortune Magazine’s “Best Workplaces in Health Care & Biopharma” and Glassdoor’s “Best Places to Work”. St. Jude is one of the best‑funded research institutes in the US with an annual budget of over $2 billion per year (https://(Use the "Apply for this Job" box below).).

• Mission and
  
  Purpose:
  
  e, working is more than just a job — it’s a calling. Each member of St. Jude is united by a shared purpose: finding cures and saving children. In addition to the meaningful work you will undertake, we offer a range of perks to enhance your experience.
• Community and Belonging:
  St. Jude is like a warm family that welcomes you, to a large part because it is a Children’s hospital.
• The Best of Both Worlds – Industry and Academia:
  St. Jude provides academic freedom in research and industrial efficiency and resources. We have access to world‑class shared resources/facilities led by expert scientists, coupled with state‑of‑the‑art technology and funding, accelerating research productivity.
• World‑Class Benefits:
  St. Jude offers a world‑class benefits package (https://). Enjoy comprehensive healthcare, a competitive salary, tuition assistance for continued education, and exceptional work‑life balance with ample paid time off.
• Professional Growth:
  You will have access to opportunities to…