Senior Bioinformatic Research Scientist
Listed on 2025-12-02
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Research/Development
Research Scientist, Data Scientist, Biomedical Science
Join to apply for the Senior Bioinformatic Research Scientist role at St. Jude Children's Research Hospital
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Join to apply for the Senior Bioinformatic Research Scientist role at St. Jude Children's Research Hospital
The Senior Bioinformatics Research Scientist performs data analysis, data visualization, statistical analysis, experimental design, database development, mathematical modeling, and novel method development. Provides bioinformatics analysis for investigators and communicates analytical process and results.
Dr. Norman Davey Lab
We are seeking a Computational Biologist to join the Short Linear Motif (SLiM) Team, where we explore how motif-mediated protein interactions can be exploited to develop novel therapeutics. Our team integrates cutting-edge CRISPR perturbations, high-throughput peptide interactomics, and genetically encoded inhibitor screens to map the SLiM-mediated interactome and uncover disease-relevant vulnerabilities in human cells.
In this role, you will develop innovative computational approaches to accelerate the discovery, experimental characterisation, and therapeutic targeting of short linear motif interactions. You will create cutting-edge tools and resources to map, characterise, and analyse the motif-mediated interactome of human cells, generating new insights into cellular regulation and protein interaction networks that can inform the development of novel therapeutics.
Key Responsibilities:
- Experimental Design & Execution:
○ Develop tools for integrating diverse biological datasets to prioritize motif-centric hypotheses for experimental validation.
○ Create resources for comprehensive exploration of motif data.
○ Maintain meticulous records of all experiments and data.
- Support and Extension of Exist Team Resource
○ General support for the groups web presence
- Collaboration & Contribution:
○ Actively participate in the academic life of the laboratory and the St Jude Children’s Hospital
- Professional Development:
○ Present research findings at seminars and journal clubs.
○ Publish articles detailing novel methodologies and analyses.
Essential and Desirable Criteria:
Education & Knowledge:
- Essential:
PhD degree with a background in computational biology. - Desirable:
Understanding of protein biology, short linear motifs and intrinsically disordered proteins.
- Essential:
○ Experience with Unix.
○ Experience with web and database development (e.g. FASTAPI, Postgre
SQL and Ember/React)
○ Knowledge and experience in analyzing large datasets.
○ Significant publication record (or evidence of manuscript(s) being prepared for publication)
Skills:
- Essential:
○ Strong observation skills, attention to detail, and ability to maintain accurate records.
○ Excellent oral and written communication skills.
○ Excellent organizational skills, including the ability to conduct effective collaborations.
○ Excellent interpersonal skills, demonstrating flexibility and the ability to establish effective working relationships.
General:
- Essential: ○ Demonstrable excellent work ethic and time management skills. ○ Independent scientific thinking and a readiness to acquire a solid knowledge of project-relevant literature in a timely manner. ○ Highly committed, hardworking, enthusiastic, and dedicated to the research topic, with a strong interest in obtaining high-quality data and actively developing and shaping an innovative project. ○ Committed to learning new techniques/approaches required for the project.
Minimum Education and/or Training:
- Bachelor's degree in bioinformatics, cheminformatics, statistics/computer…
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