Postdoctoral Research Associate - Chemical Biology & Therapeutics
Listed on 2025-12-28
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Research/Development
Research Scientist, Drug Discovery, Biomedical Science, Biotechnology -
Science
Research Scientist, Drug Discovery, Biomedical Science, Biotechnology
Overview
A postdoc position is available immediately in the laboratory of Dr. Daniel Blair, which focuses on developing direct-to-biology screening methods to identify antibiotics. This project seeks to capitalize on our recent development of modular strategies for making small molecules (Nature 2022) and rapid tandem mass-spectrometry methods to scout chemical reaction outcomes (Nature 2024). These techniques will be deployed toward the creation of an antibiotic discovery platform.
A suitable candidate will have a background in synthetic organic chemistry and/or chemical biology; experience with microbiology or high-throughput experimentation is desirable but not required.
The project will be executed in the Department of Chemical Biology and Therapeutics e Children’s Research Hospital and builds on strong investments into a world-class infrastructure in chemical synthesis and chemical biology. Substantial resources have been deployed within the Blair laboratory to support this project, including an automated synthesis machine, fully automated preparative LC-MS, 2-dimensional LC-MS, and a state-of-the-art high-throughput chemical synthesis platform.
Responsibilities- Develop direct-to-biology screening methods to identify antibiotics.
- Apply modular strategies for small-molecule synthesis and rapid MS-based analysis to inform antibiotic discovery.
- Contribute to building an antibiotic discovery platform within the Blair laboratory.
- Background in synthetic organic chemistry and/or chemical biology.
- Experience with microbiology or high-throughput experimentation is desirable but not required.
- Hu, M. … D J Blair*. Direct-to-Biology Enabled Molecular Glue Discovery. Chem Rxiv 2025.
- Hu… D J Blair*. Continuous Collective Analysis of Chemical Reactions. Nature 2024.
- DJ Blair and co-workers “Automated iterative Csp3-C bond formation.” Nature 2022.
- https://(Use the "Apply for this Job" box below).-spec
- RF Service “Machine builds druglike organic molecules in a snap.” Science 2022.
- St. Jude is an Equal Opportunity Employer
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