Scientist; Pooled Lentiviral Editing Screening

Scientist (Pooled Lentiviral Base Editing Screening)

Location

Memphis, TN

Category

Laboratory Sciences & Support

Department

Cell and Molecular Biology

Shift

Weekday Day

Position Type

Full Time

Scheduled Weekly Hours

40

JR6129

We are seeking a highly motivated and talented scientist to join our team and lead cutting‑edge research exploring the therapeutic potential of intrinsically disordered regions. This project will harness pooled lentiviral screening platforms for base/prime editing mutagenesis to systematically perturb key molecular interactions. It offers an exciting opportunity to apply innovative high‑throughput technologies to uncover new regulatory mechanisms and identify novel therapeutic targets.

The successful candidate will play a central role in developing and implementing advanced lentiviral‑based screening pipelines across diverse biological systems, working at the interface of molecular biology, genomics, and translational discovery.

The World’s Brightest Minds Always Innovate

e Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world‑class facilities. State‑of‑the‑art technologies. Extraordinary support. And a collaborative, bench‑to‑bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, e, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children.

Key Responsibilities:

• Design, optimize, and execute pooled lentiviral screening workflows for large‑scale base/prime editing mutagenesis.
• Collaborate closely with bioinformaticians and project investigators to ensure robust experimental design, data acquisition, and analysis.
• Drive the development of innovative experimental strategies to expand and enhance existing screening capabilities.
• Contribute to collaborative research outputs, including publications and conference presentations.

Ideal Candidate:

• PhD (or equivalent experience) in Molecular Biology, Cell Biology, Genetics, or a closely related field.
• Demonstrated expertise in the design, production, and application of lentiviral vectors for genetic manipulation and screening.
• Proven track record in developing, implementing, or applying high‑throughput genetic perturbation or functional screening approaches.
• Excellent organisational, communication, and record‑keeping skills.
• Strong problem‑solving ability and capacity to work independently as well as collaboratively.

Desirable Attributes:

• Extensive experience in CRISPR‑based genome engineering in mammalian cell systems.
• Demonstrated expertise in the design, production, and application of lentiviral libraries for large‑scale screening.
• Experience with base or prime editing systems.
• Familiarity with large‑scale data generation and interpretation in screening contexts.
• Evidence of contributions to collaborative research initiatives or consortia.

About the Research Environment:

The Davey lab has recently joined the Department of Cell and Molecular Biology to launch a research program applying high‑throughput screening approaches to uncover the therapeutic potential of intrinsically disordered regions. The post‑holder will work within a collaborative, supportive team and benefit from world‑class core facilities and excellent opportunities for professional development.

What problem are we tackling? Target discovery is a critical foundation of drug development, underpinning efforts to overcome the persistent challenges of drug resistance, emerging pathogens, and complex diseases that lack effective therapies. By uncovering novel proteins and molecular pathways driving disease progression, we can enable the rational design of more selective interventions that reduce off‑target effects and improve patient outcomes.

The development of tool molecules, coupled with detailed characterisation of their inhibitory mechanisms, provides a direct bridge between phenotypic observations and small‑molecule drug design, accelerating the translation of basic discoveries into clinically actionable therapies.

What is our approach? Short Linear Motifs (SLiMs)…