Scientist- Abraham’s Lab

Join our Team!

The Abraham Laboratory in the Department of Computational Biology e Children's Research Hospital is seeking an innovative and collaborative Scientist to investigate how gene regulation and nuclear organization shape mammalian cell identity and contribute to disease, including pediatric cancers.

This is an exciting bench-based role for a hands-on experimental scientist who is passionate about uncovering the mechanisms that control gene expression. The successful candidate will study cis- and trans- regulatory mechanisms using cutting-edge molecular biology technologies and independently design and execute high-throughput functional genomics assays

Working at the intersection of molecular biology, functional genomics, and cancer biology, you will design and execute cutting-edge experiments that advance our understanding of how regulatory elements such as enhancers and super-enhancers drive normal development and disease.

As a key member of a highly collaborative multidisciplinary team, you will lead and contribute to research projects utilizing advanced genomic technologies, cell-based systems, and imaging approaches to answer fundamental biological questions with direct relevance to human health.

Ideal Candidate The ideal candidate is a highly independent, hands-on scientist with strong troubleshooting skills and a collaborative mindset. This individual will serve as a key experimental partner within a shared-resource environment, working across multiple research projects focused on gene regulation and functional genomics.

Candidates are not required to have expertise in every area listed. We welcome individuals with experience in a combination of these techniques who are eager to expand their skill set and contribute across diverse research projects. Experience in some combination of the following areas is preferred:

Molecular & Cellular Biology Molecular cloning

Cell culture and tissue culture

Viral transduction and cell line engineering

Tissue processing and sample handling

Functional Genomics & Omics Technologies Strong hands-on experience with at least one high-throughput sequencing-based assay such as:

ChIP-seqCUT&RUNATAC-seqRNA-seqHi-C or related genomic technologies

Ability to independently troubleshoot and optimize genomics workflows

Imaging & Cellular Phenotyping Immunofluorescence stainingDNA and RNA FISHConfocal microscopy

Cellular imaging-based assays

Preferred / Nice-to-Have Experience Massively Parallel Reporter Assays (MPRA)
High-throughput functional genomic screening

Research involving transcriptional condensates, enhancer biology, or gene regulatory mechanisms

Experience generating and analyzing large-scale genomic datasets

Projects This Scientist May Support Depending on their expertise and project needs, the successful candidate may contribute to initiatives involving:

MPRA-based functional genomics studiesDNA and RNA imaging assays

Transcriptional condensate biology

Enhancer and super-enhancer regulation

Genome-wide sequencing and functional genomics applications

Large-scale dataset generation and characterization efforts

This role is best suited for a scientist who enjoys being the go-to experimental expert, thrives in a highly collaborative environment, and has the technical confidence to independently drive complex research projects from concept to data generation.

What You'll DoIn this laboratory-based role, you will:

Coordinate multiple research projects, carry out bench laboratory experiments utilizing various techniques, and determine whether additional or other tools, methods, or data are required

Provide input regarding research protocols and experiments. Sets up protocols and assists in developing new laboratory techniques as required.

Monitor the quality and integrity of recorded information and data.

Identify, process, organize, interpret, review, and faithfully, comprehensively, and durably report relevant data.

Draft sections of research manuscripts.

Provide basic lab operation support to include equipment maintenance and purchasing. Monitor inventory levels and order lab supplies as needed.

Collaborate on project and analysis design under the guidance of multiple invested PIs.Set personal task-level priorities across multiple interconnected projects.

Adhere to field and lab standards for data generation and analysis.

Perform other duties as assigned to meet the goals and objectives of the department and institution.

Maintain regular and predictable attendance, especially in-person attendance at…