Manager, SOX Compliance and Technical Accounting

Manager, SOX Compliance and Technical Accounting

Location: Menlo Park, CA / Princeton, NJ / Miami, FL ONSITE

Summit Therapeutics Inc. is a biopharmaceutical oncology company focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a world‑class team of professionals passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people.

Our employees are the heart and soul of our culture, shaping our journey toward excellence.

Summit’s team is inspired to touch and help change lives through clinical studies in oncology. The company is involved in multiple global Phase 3 studies across various cancers, including:

• Non‑small Cell Lung Cancer (NSCLC): HARMONi, HARMONi‑3, HARMONi‑7
• Colorectal Cancer (CRC): HARMONi‑GI3

The Manager, SOX Compliance and Technical Accounting will be responsible for ongoing SOX compliance and be involved in complex accounting transactions including accruals, collateral accounting, and other technical areas. This role reports to the Associate Director, SEC Reporting & Tech Accounting.

• Lead the company’s SOX 404 implementation program (under COSO framework), including scoping, risk assessment, control design, testing, and remediation.
• Develop and maintain an inventory of key controls in a Risk and Control Matrix (RCM), mapping controls to the relevant financial statement line items, control type (manual vs. IT), and frequency.
• Maintain comprehensive control documentation, including narratives, flowcharts, and risk/control matrices.
• Partner with IT, FP&A, and clinical teams to develop and monitor automated controls and system dependencies, serving as a trusted advisor on IT general controls.
• Liaise with internal and external auditors to coordinate SOX scoping, testing, and remediation of findings.
• Serve as the central point of contact for all SOX audit requests and manage the process for timely completion of the audit.
• Partner cross‑functionally to strengthen entity‑level controls, business process controls, incident reporting frameworks, and reporting structures expected of a public company.
• Evaluate and strengthen controls over system access, change management, and data integrity for all in‑scope systems.
• Drive annual and quarterly SOX risk assessments and the controls certification process.
• Prepare reports and updates for the Audit Committee, external auditors, and executive leadership.
• Provide controls advisory on transformation initiatives, including system implementations, process redesigns, and M&A integrations.
• Report control effectiveness and gaps to senior stakeholders, including executive‑level presentations on project findings and recommendations.
• Educate stakeholders on control requirements and best practices, including developing checklists and testing attributes.
• Research, document, record, and communicate technical accounting matters, including journal entries for complex accounting transactions.
• Analyze and interpret new accounting standards and SEC regulations, providing appropriate accounting guidance related to various business transactions.
• Research new disclosures and FASB accounting standard updates, working with external auditors on appropriate disclosure requirements.
• Develop, create, and/or modify the company’s financial accounting policies and procedures to ensure compliance with U.S. GAAP.
• Complete special projects as assigned.
• All other duties as assigned.

• Bachelor’s degree in Accounting, Finance, Business Administration, or related field.
• CPA, CIA, or CISA certification strongly preferred.
• 5+ years of experience in internal controls, SOX compliance, and audit.
• Experience working at a public company with a quarterly reporting cadence preferred.
• Good technical knowledge of U.S. GAAP and internal controls.
• Background at a Big‑4 public accounting & audit firm strongly preferred.
• Proven track record of implementing scalable…