Principal Cybersecurity Engineer

Principal Cybersecurity Engineer Pac Bio  | Menlo Park, CA | OnsiteOPPORTUNITYPacBio's long-read sequencing platforms help scientists and clinicians resolve genetically complex problems in human health, agriculture, and basic research. The information we protect, including human genomic data, proprietary chemistry and instrument designs, and the research of the customers who trust our platforms, is among the most sensitive that exists.

We are seeking a Principal Cybersecurity Engineer to strengthen and mature Pac Bio's security program.

ABOUT

THE ROLE As Principal Cybersecurity Engineer, you will own security architecture and engineering end to end across Pac Bio's network, storage, high-performance computing (HPC), and cloud environments. You will design and implement controls, harden the systems we run, and ensure those controls stand up to auditors, customers, and attackers alike.

You will serve as the technical lead for Pac Bio's ISO 27001 certification and for security-related SOX IT general controls, translating requirements into practical, well-evidenced controls that fit how our scientists, engineers, and operations teams work.

This senior individual contributor role reports to the Head of Information Technology and sets the technical direction for cybersecurity s role requires comfort moving between hands-on engineering, architecture, audit, and executive communication, and the ability to lead across IT, R&D, Software Engineering, Operations, and Finance without direct authority.

RESPONSIBILITIES Security architecture and roadmap:
Define and own Pac Bio's security architecture, standards, and multi-year engineering roadmap across enterprise, HPC, and cloud environments. Prioritize work based on risk and track progress with clear, measurable outcomes.

ISO 27001 certification:
Serve as technical lead for Pac Bio's ISO 27001 program. Help define ISMS scope, conduct risk assessments, implement and evidence Annex A controls, maintain the Statement of Applicability, and lead preparation for internal, certification, and surveillance audits.

SOX IT general controls:
Own security-related ITGCs for financially significant systems, including logical access, privileged access, change management, and logging and monitoring. Partner with Finance, Internal Audit, and external auditors on control design, testing, evidence, and timely remediation of deficiencies.

Network security:
Own the security design of Pac Bio's networks, including segmentation, firewalls, secure remote and zero-trust access, wireless, and DNS and email security.

Storage, data protection, and resilience:
Secure large-scale research and enterprise storage through access controls, encryption, and data classification. Design and regularly test controls that allow Pac Bio to prevent, contain, and recover from disruptive cyberattacks, including immutable backups, recovery testing, and containment playbooks.

HPC and cloud security:
Secure the HPC clusters and cloud environments (AWS, Azure, and/or GCP) that support sequencing data analysis and R&D, including identity and privilege design, workload isolation, posture management, and security enforced through infrastructure as code.

Device and server hardening:
Define and enforce secure configuration baselines (e.g., CIS Benchmarks) for Windows, macOS, and Linux endpoints and servers, hypervisors, network devices, and IoT devices. Drive configuration compliance monitoring, vulnerability management, and patching with infrastructure and IT teams.

Identity and access:
Strengthen identity and access controls across the enterprise, including SSO, MFA, privileged access management, and periodic access reviews.

Threat detection and response:
Own EDR, SIEM, and MDR capabilities and the vendor…