Principal Development Scientist

Overview

We are seeking a highly motivated Principal Scientist to join our Deeside process development team. Our bioconjugation scientists play a critical role in bridging the gap between small‑molecule chemistry and large‑molecule biologics, primarily focusing on the development and scale‑up of Antibody‑Drug Conjugates (ADCs) and other bioconjugates. You will execute and manage the delivery of projects supporting our clients early‑stage research and then progress lead candidates into clinical‑scale manufacturing, ensuring high‑quality drug candidates are ready for the clinic.

• Process Design & Optimization:
  Independently design and execute experiments to develop scalable bioconjugation and purification processes.
• Scale‑up & Tech Transfer:
  Transition processes from bench‑top research to larger‑scale production while maintaining product quality.
• Downstream Processing:
  Optimize purification workflows using ÄKTA chromatography systems and Tangential Flow Filtration (TFF).
• Analytical Characterization:
  Perform in‑depth product analysis using HIC, SEC, IEX, and LC‑MS to ensure quality, purity and stability.
• Data‑Driven Innovation:
  Apply Quality by Design (QbD) and Design of Experiments (DoE) principles to identify critical process parameters.
• Collaboration:
  
  Work cross‑functionally with Project Management, Process Introduction, Analytical, and Quality teams during process development and transfer into clinical manufacturing.

• Education: BSc, MSc or PhD in Chemistry, Biochemistry, Chemical Biology/Engineering or similar; minimum 10 years of relevant industry experience.
• Technical Expertise: Deep understanding and hands‑on experience with conjugation of small molecules to antibodies or other proteins; skilled in all aspects of downstream process development, including reactive chemistry.
• Highly advantageous: Experience in high‑throughput / parallel process & reaction screening and process optimisation and validation for late‑phase / commercial stages.
• Experience: Working with highly potent molecules and containment strategies is advantageous; knowledge of cGMP and EU, MHRA and FDA regulations.
• Analytical
  
  Skills:
  
  Proficiency in interpreting complex data using Chemstation, Chromeleon, Design Expert.
• Soft Skills and Mindset: Excellent interpersonal and communication skills, proactive, attention to detail, problem‑solving, organisational and planning abilities, emotional resilience and a positive attitude.

Competent with Microsoft Office suite (Outlook, PowerPoint, Word, Excel).

A competitive salary, pension scheme, private healthcare, retail discounts through reward gateway, cycle‑to‑work scheme, 26 days annual leave plus bank holidays, death‑in‑service coverage, on‑site health and wellbeing support, medical consultation and physiotherapy, 24/7 employee assistance program, and training and opportunities for further career development.

Sterling Pharma Solutions is an equal opportunities employer and positively encourages applications from suitably qualified and eligible candidates regardless of sex, race, disability, age, sexual orientation, marriage or civil partnership, pregnancy or maternity, religion or belief.