Computational Protein Engineer

Computational Protein Engineer page is loaded## Computational Protein Engineer locations:
Braytime type:
Full time posted on:
Posted Yesterday time left to apply:
End Date:
January 30, 2026 (4 days left to apply) job requisition :
REQ-10267

It's fun to work in a company where people truly believe in what they are doing!

Reporting to the R&D Director, the Computational Protein Engineer will be a critical, hands-on contributor, leveraging state-of-the-art computational methods—including machine learning (ML) and physics-based simulations—to drive the design and optimization of enzymes and antibodies. This role is central to our R&D objectives, focusing on improving key properties such as stability, expression, affinity, enzymatic activity, and solubility of our high-value reagents. The role holder will take responsibility for the management of their own R&D projects and proactively work towards their completion within agreed time frames.

The opportunity to execute protein expression and/or protein characterization will also be provided.
** Key Duties and Responsibilities
** The successful candidate will be responsible for the execution and leadership of computational protein engineering projects, including:
** Computational Duties**
* ** Protein Optimization:
** Utilize both machine-learning and physics-based simulation methods to rationally design and improve the properties (stability, activity, solubility, affinity, etc.) of novel enzyme and antibody reagents.
* ** Predictive Model Development:
** Take experimental high-throughput screening (HTS) data for antibody and enzyme mutants and design robust predictive models for generating novel, high-value mutants using a Bayesian optimization approach.
* ** Molecular Simulation:
** Design, execute, and analyze classical molecular simulation (Molecular Dynamics and Monte Carlo) studies to probe protein dynamics and interaction mechanisms.
* ** Force Field Development:
** Customize or create small molecule force fields for accurate computational studies of non-covalent interactions between small molecules and antibodies, and for investigating transition states in enzyme-substrate complexes.
* ** Pipeline Development:
** Develop, validate, and maintain high-performance computational workflows and pipelines for protein design.
** Research and Development Tasks**
* ** New Product Development:
** Contribute to the development and launch of new products in conformance with the Neogen NPI Process, including developing timelines and liaising with Product Managers.
* ** Troubleshooting & Optimization:
** Troubleshoot and optimize computational and experimental assay designs as required.
* ** Record Keeping:
** Maintain excellent, detailed records of all computational models, simulation parameters, and results using an electronic lab notebook system.
* ** Interdepartmental

Collaboration:

** Actively liaise with R&D teams (Biochemical, Molecular Biology, etc.) to integrate computational designs with experimental data in a robust, iterative design-build-test-learn cycle.
** General**
* ** Reporting:
** Present research findings, methodologies, and progress to the Research Director and other R&D leadership.
* ** Documentation:
** Prepare all relevant documentation, including technical reports, protocols, and SOPS for computational workflows.
* ** Scientific Support:
** Provide expert scientific support to other departments and teams as needed.

Come Be Part Of A Mission that Matters!

From inside the farm gate to our dinner plates, Neogen protects the world’s food supply. Through a variety of animal healthcare products, to food safety solutions for dangerous bacteria, allergens, toxins, drug residues and much more, Neogen is there — and you can be too.
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