Director, Manufacturing

Job Title:

Director, Manufacturing

Career level:

F
Introduction to role:
Be part of history in the making. AstraZeneca is building its first biologics manufacturing campus in Singapore — a groundbreaking USD 1.5 billion investment that will serve as a global hub for innovation and excellence.
This state-of-the-art facility will deliver end-to-end Antibody-Drug Conjugate (ADC) capabilities with different manufacturing units/buildings in one campus Small molecule- chemical API production
Large molecule- monoclonal antibody manufacturing
Conjugation
Fill-and-finish operations, including sterile filling and lyophilization
Final secondary packaging
The campus will be equipped with modern digital and automation infrastructure, enabling autonomous manufacturing powered by artificial intelligence. In addition, it will be designed for carbon neutrality, embedding sustainability into every aspect of operations and setting a new benchmark for environmentally responsible biologics manufacturing.
We are looking for passionate individuals with relevant experience who thrive in dynamic environments and bring a “make-it-happen” attitude. Joining us means contributing to a project that will not only transform AstraZeneca’s global supply chain but also advance life-changing medicines for patients everywhere.
If you’re ready to shape the future of biologics and be part of a once-in-a-generation project, we want you on our team.
We are recruiting Director, Manufacturing to lead and manage the different manufacturing units across our campus.
Accountabilities:
Operational Leadership:
Establish and lead all operational activities for the Manufacturing unit including process execution, staffing, safety, compliance readiness and adherence to unit budget.
Design Ownership:
Serve as the Manufacturing Unit operational owner during Basic Design and Detailed Design, ensuring operational needs are built into facility and equipment decisions.
Multi-functional

Collaboration:

Partner with Global Engineering and work across QA, QC, Engineering, and Demand & Supply to shape facility layout and equipment strategy, guiding process and equipment decision-making.
Compliance Leadership:
Drive consistency to cGMP, occupational safety and local regulatory expectations, ensuring inspection readiness and sustainable compliance.
Resource Strategy:
Plan, manage and control resource allocation to secure future manufacturing capability and deliver strategy.
Improvement and Profitability:
Direct new initiatives and improvement programs to strengthen compliance, enable continuous improvement, advance technical excellence and enhance profitability.
Team Leadership:
Recruit, set goals and manage performance for a multi-functional team that delivers to time, cost and quality standards.
Safety and Work Standards:
Lead a multi-disciplinary team to define and achieve manufacturing safety and work standards and associated procedures that meet business needs and satisfy external regulators.
Business Needs to Resources:
Define business requirements, gain approvals and translate needs into specific resource plans.
Coaching and Development:
Coach and develop all Process Execution team members to build depth, flexibility and engagement.
Senior Stake holder Engagement:
Develop senior-level relationships to resolve issues, optimize business performance and surface future improvement opportunities.
KPI Ownership:
Own and drive KPIs across productivity, quality, safety, schedule consistency and cost, using data to prioritize and act.
Culture and Ways of Working:
Foster an inclusive, safety-first environment where ideas are tested, learned from and grown.
Process Capability and Digital:
Drive process capability improvement, lean operations and digital automation to reduce variability and accelerate throughput.
Essential Skills/

Experience:

Strategic Planning & Resource Management
Ability to define business needs, gain approval and translate these needs into specific resource requirements.
Experience planning, managing and controlling overall allocation of resources to ensure future capability to implement manufacturing strategy.
Ability to develop senior-level contacts to resolve issues,…