Principal Enterprise Compliance Architect

McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve – we care.

What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow’s health today, we want to hear from you.

We are seeking a Principal Enterprise Compliance Architect to provide enterprise-wide leadership across large-scale ERP transformation initiatives, with a focus on SAP S/4

HANA and master data governance. In this role, you will define and drive compliance architecture strategies, ensuring controls, risk management, and governance are embedded within core ERP design. You will partner with technology, finance, and compliance leaders to deliver scalable, automated, and audit-ready processes across key business areas such as order-to-cash, procure-to-pay, and record-to-report. This role plays a critical part in enabling “compliance by design” and strengthening enterprise control maturity.

• Define and govern enterprise compliance architecture strategy for SAP S/4
  
  HANA transformation programs
• Lead design and implementation of embedded controls, workflow governance, and audit-ready ERP processes
• Align SAP configuration and system design with SOX/SOC control requirements and business process controls
• Drive compliance architecture for master data governance (Simple MDG), ensuring auditability and end-to-end control coverage
• Lead integration of compliance frameworks across ERP and adjacent platforms within V4 and enterprise programs
• Design and implement automation strategies for approvals, segregation of duties (SoD), and audit trails
• Integrate ERP systems with GRC platforms (e.g., Service Now IRM, SAP GRC) to support continuous monitoring and control testing
• Provide architectural guidance to cross-functional ERP, data, and platform teams for compliance-driven decision making
• Lead governance reviews, resolve complex cross-domain issues, and advise executive stakeholders on risk and trade-offs
• Other duties may be assigned as needed to meet Company goals.

• Degree or equivalent and typically requires 13+ years of relevant experience
• 12–15+ years of experience in enterprise architecture, ERP transformation, or IT compliance roles
• Extensive hands‑on experience with SAP S/4
  
  HANA implementations in enterprise environments
• Strong experience with master data governance (MDG), including customer, vendor, and material domains
• Deep expertise in SOX, SOC, ITGCs, and business process controls
• Experience integrating ERP platforms with GRC tools (e.g., Service Now IRM, SAP GRC)
• Proven experience designing and implementing compliance-by-design frameworks in ERP systems
• Experience leading large-scale, cross-functional transformation programs and influencing senior stakeholders

• Experience in healthcare or other highly regulated industries
• Strong understanding of automation strategies for compliance and audit readiness
• Experience driving enterprise-wide standardization of controls and governance frameworks.

We are Flex and Connect with 2 days a week in office

We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson, please .

$149,600 - $199,500

McKesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category. For additional information on McKesson’s full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page.

McKesson is committed to being an Equal Employment Opportunity Employer and offers opportunities to all job seekers including job seekers with disabilities. If you need a reasonable accommodation to assist with your job search or application for employment, please contact us by sending an email to (United States) Disabili or (Canada)  Resumes or CVs submitted to this email box will not be accepted.