Senior Principal Scientist, Pre-Formulation and Materials Science

Senior Principal Scientist, Pre-Formulation and Materials Science

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate everyday to make the world a healthier place.

To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.

Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.

This Senior Principal Scientist position will be a strong scientific and leadership role within the Early Formulation Science and Drug Delivery (EFS-DD) group, supporting early-stage drug and drug product design, materials science characterization and strategy, and biopharmaceutics understanding as well as early clinical drug delivery strategy of new small molecules. The selected candidate will interface with multi-disciplinary research project teams and cross‑functional management to provide guidance, input and direction on molecular design, dosage form design, solid form strategy, and biopharmaceutics aspects of pre‑clinical and clinical candidate development.

The role will also focus on developing and demonstrating leadership and drug delivery strategy skills within the Drug Product Design and Supply department, which functions as part of the larger Pharmaceutical Sciences division.

• Understanding of connectivity of molecular structure, solution kinetics, thermodynamics, diffusion and permeation of molecules across membranes
• Strong fundamental understanding of molecular and supramolecular interactions of small molecules in aqueous environments
• Ability and interest to understand and probe molecular/supramolecular interactions of small molecules in common enabling drug delivery technologies; desire to optimize system properties to achieve required delivery profiles for pre‑clinical and clinical studies
• Strong fundamental understanding of principles governing crystallization and polymorph behavior, characterization techniques for crystalline and amorphous solid forms, and impacts of solid form on stability, manufacturability, and bio‑performance of small molecule drug candidates and drug products
• Efficient application of existing advanced modeling and simulation tools for predictive performance of oral absorption and systemic exposure (pharmacokinetics) in pre‑clinical and clinical studies
• Development and advancement of the concepts of early translational biopharmaceutics with a focus to improve predictive capabilities by linking in vitro drug and drug product performance attributes to in vivo performance attributes
• Lead matrix teams of scientists across multiple levels to deliver portfolio and initiative breakthroughs
• Lead scientific strategy and set direction for advances in oral, small molecule drug delivery through interaction with organizational thought leaders and cross‑functional management
• Maintain an awareness of and contribute to current relevant scientific literature
• Conduct novel scientific research and present significant findings via internal and external presentations or publications

• Provide scientific advances, leadership, and strategic direction for the fundamental understanding of key connectivity of molecular structure, solution and diffusion behavior, and permeation characteristics to enable optimal drug formulation and drug delivery system design
• Integrate pharmaceutics, physical organic chemistry, biophysical chemistry, supramolecular chemistry, materials science, and fundamental biopharmaceutics principles into drug candidate screening and design, formulation design, solid form strategy, and ultimately project direction
• Teach and mentor colleagues across the Pfizer organization
• Cultivate sustainable and effective relationships with internal partners and stakeholders, i.e., partner lines in Medicinal Design, Pharmaceutical…