Assistant Scientist - Biophysics​/SPR

At X-Chem
, it is our mission to leverage the world’s leading drug discovery platform to help create molecules that will improve human health. At X-Chem, we do more than screen compounds. We help you make confident decisions that move science forward. Our integrated platform combines DNA-encoded libraries, medicinal chemistry, advanced modeling and proprietary AI into a powerful and precise discovery engine. Everything is connected through Chemomics, our approach to unlocking value from every data point.

Whether you’re exploring a new target or refining a lead, we help you discover high-quality molecules with greater speed, insight and control.

This position will support the development and execution of biochemical and biophysical assays, with a particular focus on Surface Plasmon Resonance (SPR). The successful candidate will contribute to assay development, optimization, execution, data analysis, troubleshooting, and reporting in support of drug discovery programs. Previous SPR or Biacore experience is considered an asset; candidates with strong biochemical or biophysical assay experience and an interest in developing SPR expertise will also be considered.

The ideal candidate has 1 to 3 years of laboratory experience

This position will be located at X-Chem's offices in Montreal, QC Canada.

Job Responsibilities:

• Perform and support biochemical and biophysical assay activities, including SPR-based experiments.
• Execute established protocols and experimental plans, including repeat analyses, troubleshooting, and investigation-related activities.
• Support assay and method development, optimization, verification, validation, and transfer activities.
• Prepare buffers, reagents, samples, and dilution series accurately and reproducibly, including pH adjustment and verification.
• Maintain and complete accurately the laboratory documentation.
• Ensure data integrity, and accuracy of all generated, analyzed, and reported results.
• Maintain laboratory equipment and coordinate routine instrument checks, troubleshooting, and service activities as required.
• Follow laboratory safety requirements, established procedures, and good scientific practices.

Skills and

Qualifications:

• BSc in Biochemistry, Biophysics, Biology, Biotechnology, Chemistry, or related scientific discipline with 1 to 3 years of relevant hands-on laboratory experience.
• Relevant hands-on laboratory experience with biochemical, biophysical, or related life-science assays.
• Strong pipetting skills and experience preparing buffers and solutions, including the use of a pH meter.
• General understanding of protein chemistry, biomolecular interactions, and reaction and/or enzyme kinetics.
• Experience executing laboratory protocols independently with strong attention to detail and reproducibility.
• Ability to analyze, interpret, and troubleshoot experimental data.
• Experience supporting method development, optimization, verification, validation, and/or method transfer.
• Strong understanding of laboratory documentation, data integrity, traceability, and scientific reproducibility.
• General knowledge of laboratory safety, chemical handling, and good laboratory practices.
• Strong organizational skills and ability to manage multiple experiments or projects concurrently.
• Good written and verbal communication skills and ability to work effectively within multidisciplinary project teams.

Preferred Qualifications

• SPR experience is preferred but is not a mandatory requirement for this position.
• Understanding of biomolecular interaction kinetics and affinity, including association rate, dissociation rate, and equilibrium binding constants.
• Experience interpreting binding curves or sensor grams and evaluating assay quality.
• Experience in a drug discovery, biotechnology, pharmaceutical, or…