Associate Director, R&D Chemistry, Peptidomimetics

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking an Associate Director (Peptidomimetics), R&D Chemistry to play a pivotal role in expanding Regenerons peptidomimetic antibody-conjugate drug discovery capabilities, driving the development of innovative therapeutics across diverse research areas while leveraging the companys expertise in biologics and genetic medicines. The role requires deep expertise in peptidomimetic, medicinal, and synthetic organic chemistry, including SAR optimization, linker-payload synthesis, and advanced bioconjugation strategies.

Success depends on applying both chemical and biological approaches to overcome drug discovery challenges and advance development candidates. The individual will also provide strong leadership, collaboration, and communication to guide cross-functional teams in a highly innovative research environment.

Directly supervise and manage the day-to-day activities of the R&D Chemistry Peptidomimetic group, providing vision, inspiration, and both short-term and long-term goals. Communicate priorities, policies, and goals of Regeneron Senior Leaders to the group.

Perform medicinal chemistry inspired and SAR-driven generation of novel peptidomimetic drug modalities, using synthetically feasible and simplistically designed linkers to provide overall optimal in vitro and in vivo properties of antibody-conjugated therapeutics

Troubleshoot and optimize peptide potency and stability using standard peptide-based principles (e.g., Ala scans), non-natural amino acid incorporation, alpha-Me/N-Me peptide backbone modifications, and other medicinal chemistry strategies that are guided by in vitro assays, plasma/serum stability, and met .

Champion and lead the R&D Chemistry Peptidomimetic efforts on internal/external project teams, and demonstrate the ability to multi-task and parallel process to add to our continuous pipeline of Regeneron development candidates

Identify new strategies and technologies (e.g., linker and payload design) to improve on existing Regeneron platforms for pursuing novel synthesis and bioconjugation of peptidomimetic drug modalities

Actively participate in departmental, cross-functional, leadership, and external meetings to contribute expertise and to represent the vision of the R&D Chemistry Peptidomimetic group.

Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations.

This is an on-site position located in our Hawthorne, NY facility

Occasional travel to our nearby Tarrytown facility may be required

Ph.D. in peptide and/or synthetic organic chemistry or a related field.

Minimum Of 10 Years Of Professional Industry Experience.

Extensive drug discovery experience with antibody-targeted peptidomimetic drug modalities, experience with the synthesis and manufacturing of peptidomimetic payloads and linkers, expertise in modern methods in medicinal chemistry structure-activity relationships, and a deep understanding of biological MOAs (extracellular/intracellular target evaluation, ADME/PK, PD/efficacy, toxicological evaluation).

A track record of success in the field of either peptidomimetics, small molecules or antibody targeted therapeutics (i.e., advancement of molecules into the clinic) with experience building and leading teams is required.

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or…