Senior Data Manager, Clinical Data Management

Senior Data Manager, Clinical Data Management

We are looking for a Senior Clinical Data Manager who can independently lead data management for multiple cognitive and psychiatric clinical studies. This is a senior‑level, hands‑on role for someone who thrives in a fast‑paced environment, can run studies end‑to‑end, and partners closely with cross‑functional teams to deliver high‑quality, analysis‑ready data.

As the Senior Clinical Data Manager, you will own all data management activities from study start‑up through database lock, including:

• Leading data management for multiple clinical trials with minimal oversight.
• Serving as the primary CDM lead for internal teams, CROs, and external vendors.
• Designing eCRFs and overseeing database build, UAT, and system release.
• Developing and executing core DM documents (e.g., Data Management Plan, edit checks, reconciliation plans, CRF guidelines).
• Managing data cleaning, query review, external data integration, and database quality checks.
• Driving database lock and ensuring submission‑ready data packages.
• Collaborating with Clinical Ops, Biostats, Data Engineering, and Data Science to ensure data quality and readiness.
• Ensuring compliance with ICH‑GCP, FDA, GDPR, HIPAA, and internal standards.
• Contributing to process improvement and helping scale CDM capabilities across Alto’s portfolio.
• This role requires someone who is confident leading studies independently, setting timelines, managing vendors, and driving deliverables to completion.

Remote or On‑site (Mountain View, CA)

$140,000 - $160,000

Compensation includes a base salary, an annual target bonus, and an equity grant.

• 7+ years of clinical data management experience, including 3+ years in a senior/lead role.
• Proven ability to independently run studies from protocol review through database lock.
• Experience managing CROs, EDC systems, and external data vendors.
• Strong understanding of CDISC standards (CDASH, SDTM) and DM best practices.
• Experience in neuroscience, psychiatry, or cognitive health is a plus.
• Excellent communication, problem‑solving, and project management skills.
• Familiarity with SAS, SQL, Python, or similar tools is beneficial.
• A passion for advancing data‑driven clinical research.

At Alto Neuroscience, you will play a pivotal role in advancing precision psychiatry and improving how mental health disorders are treated. Join us in building the next generation of personalized neuroscience‑based therapeutics.

Alto Neuroscience is an equal‑opportunity employer that does not discriminate on the basis of sex, age, race, color, religion, marital status, sexual orientation, gender identity, pregnancy, disability, or any other characteristic protected by law. We offer a welcoming and inclusive environment in service to one another, our products, the diverse consumers we represent, and the communities we call home. We do all of this with kindness, empathy and respect for each other.

The above is intended to describe the general content of and requirements for the performance of this job. It should not be construed as an exhaustive statement of duties, responsibilities or physical requirements.