Director, Medical Information

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026.

Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial.

In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN
1701 and XEN
1720 (targeting Nav
1.7) and XEN
1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

We are seeking a Director, Medical Information to support the establishment, scaling, and evolution of the Medical Information (MI) function s role drives functional priorities for, and execution of medical inquiry management, scientific response content development, contact center operations, and digital medical information capabilities to support Medical Affairs, Clinical Development, and Commercial launch readiness. To be successful in this role, you must be a strong operational leader with a service-oriented and collaborative mindset.

You are someone driven by scientific rigor, operational excellence, and cross-functional alignment to manage a scalable, future-ready MI ecosystem that integrates data, content, and digital innovation to support healthcare professionals, patients, and internal stakeholders.

This position reports to the Executive Director, Medical Information and partners closely with Pharmacovigilance & Drug Safety, Quality, Regulatory, Commercial, Market Access, Clinical Development, Legal/Compliance, and Medical Affairs. The position plays a critical role in launch readiness and operational execution, ensuring Xenon delivers high-quality, compliant, and timely medical information for our products and pipeline.

This position will be based out of Boston, MA, USA in our Needham office. This role is a hybrid position, requiring a minimum of 2 days per week in the office. We will consider other jurisdictions for exceptional candidates.

• Operationalize the end-to-end vision, strategy, and execution of the Medical Information function, including contact center operations, digital capabilities, and scientific content management, including readiness for commercialization and oversight of internal/external resources.

• Build and deploy scalable operating models for MI, including SOPs, workflows, and governance in partnership with Legal, Compliance, PV/DS, Quality, Clin Dev, and Med Affairs.

• Work with manager and Medical Affairs stakeholders to refine and execute process for the authoring and lifecycle management of Standard Response Letters (SRLs) and scientific content, ensuring accuracy, consistency, and alignment with clinical data, publications, and regulatory requirements.

• Support MI alignment with enterprise efforts in omnichannel MI delivery and self-service portals.

• Execute and manage MI contact…