Clinical Trial Manager

Why Work With Us?

At Candel Therapetics, our people drive our success. We value diversity, collaboration, and bold thinking in a supportive, mission-driven environment. Like a team, we show up for each other and stay focused on making a difference for patients and families. Our leadership is transparent and empowering, and our culture is built on trust, flexibility, and accountability, encouraging ownership and innovation every day.

Candel Therapeutics is a clinical-stage biopharma company developing off-the-shelf, multimodal immunotherapies that stimulate personalized, systemic anti-tumor responses. Our platforms use genetically modified adenovirus and HSV constructs. With positive Phase 3 results for our lead candidate, it’s an exciting time to join us and help bring transformative cancer treatments to patients. Learn more:

We’re looking for a Clinical Trial Manager (CTM) to help us lead execution of our Phase 3 oncology trials with precision, confidence, and heart. This is a fast-paced, high-accountability role where you’ll collaborate cross-functionally, ensure inspection readiness, and keep our clinical operations running smoothly.

If you’re a self-motivated leader who thrives on solving problems, navigating complexity, and working with humility, this role is for you.

• Provide operational management and leadership to cross-functional study team to execute the clinical study per agreed upon timelines, budget and quality.
• Drive startup through closeout: IRB, contracting, site selection, initiation, monitoring, and metrics tracking.
• Support inspection readiness and contribute to critical regulatory milestones.
• Co-monitor with CRAs; review site visit reports and elevate issues proactively.
• Maintain essential documents and trial master file (TMF) accuracy.
• Collaborate with internal teams and vendors to ensure alignment and effective execution.

• 4+ years of CTM or site management experience in oncology clinical trials is required
• Deep understanding of Phase 3 trial conduct and in-house operational models
• Familiarity with ICH/GCP, FDA/EMA guidelines
  , and regulatory best practices
• Strong leadership and problem-solving skills; ability to manage ambiguity and prioritize independently
• Exceptional communication skills and comfort interacting with senior stakeholders
• Prior CRA experience is a plus
• High emotional intelligence and a “scrappy but humble” mindset

• You know how to get things done without needing step‑by‑step instructions.
• You value collaboration over ego and strive to lift others as you grow.
• You’re excited to join a growing company and make a tangible impact.
• You care about patients, science, and people
  —in that order.

This is a hybrid position based in the Greater Boston area. Onsite presence of 1–2 days/week is expected. Occasional travel (~20%) may be required for site co‑monitoring or inspections.