Senior Scientist; Portfolio Generation

Senior Scientist (Portfolio Generation)

£41,700 - £51,300 plus benefits

Department: Therapeutic Innovation, R&I

Reports to: Vice President of Portfolio Generation

Location: CRUK Scotland Institute, Glasgow (high flex: 1 to 2 days per week on site)

Contract type/hours: Permanent, Full time 35 hours per week (flexible working requests will be considered)

Closing date: Sunday 8th March 23:55pm

Interview Date: Approximately week commencing 23rd March

Interview process: Competency based interview with task/presentation

At Cancer Research UK, we exist to beat cancer.

As a Senior Scientist in our portfolio Generation Team, you will play a key role in identifying and shaping early therapeutic opportunities for TI drug discovery. You’ll review and evaluate new ideas emerging from academic groups, including those identified by the Network Translation Team, to assess their potential for further development.

You will support the creation of effective, de‑risking workplans that move promising opportunities toward a clear decision on TI portfolio entry. As part of the Therapeutic Catalyst schemes, you’ll review Expressions of Interest, recommend which should progress to full proposal, and work closely with PI labs to develop costed proposals and detailed workplans for CRUK committees or other translational funding routes.

Following project approval, you’ll coordinate multiple Therapeutic Catalyst initiatives, helping explore routes for TI support and informing progression decisions. You will also help drive productive interactions with academic researchers and external partners to support the development of high‑potential therapeutic concepts. Every role at CRH is united by a single mission: beating cancer sooner. We carry out work that matters—impacting patients, families, and the future of science.

• Development of multiple new opportunities from concept review, through evaluation and de‑risk to a decision point on drug discovery portfolio entry (in collaboration with key drug discovery stakeholders)
• Support the development and delivery of workplans to agreed inflection points
• Act as a primary point of contact between academic collaborators and CRH‑TI within Portfolio Generation space as required
• Assist the triage of Therapeutic Catalyst expressions of interest and the development of full proposals
• Lead multiple Therapeutic catalyst projects to required/approved endpoints including option to accelerate via additional TI support
• Make scientific recommendations to relevant review groups/leadership teams
• Undertake other tasks as necessary to contribute to the CRH‑TI objectives

• PhD or equivalent experience in relevant cancer field
• Relevant experience of early drug target discovery and the evaluation process (target selection, validation, technical feasibility etc.), preferentially developed in a drug discovery environment
• Previous experience of working with PI’s and helping to deliver early translation projects in cancer discovery
• Excellent interpersonal skills with the ability to network and build strong working relationships
• Strong scientific understanding of what it takes to drive exciting opportunities towards future drug discovery starts (biology and early drug discovery)
• An appreciation of the use of preclinical cancer models to support therapeutic discovery
• Proven ability to contribute at a technical level to multiple programmes simultaneously
• Collaborative team player, but also a highly self‑motivated individual able to prioritise and manage time effectively with the highest levels of quality, productivity, and urgency in delivery
• Maintenance of the highest standards of records, data and documentation
• Ability to conceive and manage workplans across teams aimed at de‑risking a therapeutic opportunity area within the therapeutic catalyst scheme
• Ability to embed across multiple scientific areas:
  Flexible, unafraid of failure, able to focus on the key experiments

Bold: Act with ambition, courage and determination

Credible: Act with rigour and professionalism

Human: Act to have a positive impact on people

Together: Act inclusively and collaboratively

We’re looking for people who can believe…