Oncology Early Stage Clinical Scientist; Director, Non-MD

Oncology Early Stage Clinical Scientist (Director, Non-MD)

Join Pfizer as an Oncology Early Stage Clinical Scientist (Director, Non-MD). This role leads and coordinates the development of multiple studies of novel biological and small molecules for first‑in‑human (FIH), proof‑of‑mechanism (POM), early signs of efficacy (ESOE), and proof‑of‑concept (POC) studies in oncology.

Work closely with the Global Development Lead and the development team to establish, lead, coordinate, and execute the early oncology clinical development plan(s). Lead the development of the clinical protocol and serve as an individual contributor on clinical teams to meet enrollment and study delivery timelines. Collaborate with interdisciplinary teams (Research Units, Biostatistics, Clinical Pharmacology, Precision Medicine, Digital Medicine) to ensure the full scope of Oncology Early Stage Development is represented.

• Partner closely with the Global Development Lead (GDL) to execute the clinical development strategy and plan for assigned molecule(s)/indication(s).
• Provide scientific leadership and execution of clinical studies, delivering high quality trial execution, safety assessment, and interpretation of clinical study results.
• Support execution for all FIH programs through proof‑of‑concept.
• Set the clinical data review strategy, ensuring quality data, review emerging clinical data and trends, and present relevant data to appropriate teams, governance bodies, and stakeholders.
• Conduct data review, analysis and interpretation of clinical trials data together with GDL, Clinical Safety, and Biostatistics.
• Serve as technical resource for clinical issues raised by internal and external collaborators, investigators, consultants, and contractors.
• Support development of publications, abstracts, and presentations.
• Participate in project teams to assist in the implementation of clinical development and contribute to key milestones (e.g., start‑up and delivery of ESOE and POC trials).
• Lead preparation of clinical protocols and support critical documents including clinical development plans, INDs, annual reports, CSRs, investigator brochures, statistical analysis plans, and regulatory documents.
• Foster a transparent environment that builds strong partnerships and mutual trust among teams and therapeutic areas.
• Coordinate with other clinical research activities within Oncology Research Development (ORD) and the broader Worldwide Research and Development (WRD) organization.
• Develop effective collaborations with key internal and external partners, such as project leaders, research units, biostatistics, regulatory affairs, clinical pharmacology, human genetics, translational oncology, precision medicine, and development operations.
• Partner with Translational Oncology and Biomarker teams to integrate biomarker plans into relevant programs for early efficacy signs and POC, and patient stratification.
• Establish and support relationships with external experts, consultants, key opinion leaders, regulators, and investigator networks to integrate the latest clinical thinking and guidelines into development plans and study designs, and manage study recruitment, analysis, interpretation, and presentation of results.
• Maintain up‑to‑date knowledge of scientific and clinical literature in relevant therapeutic areas, including key clinical development issues.
• Perform other duties as assigned related to clinical programs.
• Support functional area priorities and contribute to or lead departmental initiatives as requested.

• Relevant PhD or Pharm
  
  D and a minimum of 5 years of experience in a similar role in industry/CRO.
• MS and a minimum of 7 years of experience in a similar role in industry/CRO.
• BA/BS and a minimum of 10 years of experience in a similar role in industry/CRO.
• Clinical research experience in Phase 1 oncology, on the side of the sponsor leading studies.
• Experience in or strong understanding of oncology drug development, especially in early development.
• Strong knowledge of clinical procedures, ICH guidelines, GCP and familiarity with FDA, EMA, and global regulations.
• Strong scientific…