Senior Medical Science Liaison

About Summit

Ivonescimab, known as SMT
112, is a novel, potential first‑in‑class investigational bispecific antibody that combines the effects of immunotherapy via PD‑1 blockade with anti‑angiogenesis through VEGF inhibition in a single molecule. It displays unique cooperative binding to each target with higher affinity when both PD‑1 and VEGF are present. Summit has begun clinical development of ivonescimab in non‑small‑cell lung cancer (NSCLC) with three active Phase III trials:

• HARMONi – evaluate ivonescimab plus chemotherapy versus placebo plus chemotherapy in patients with EGFR‑mutated, locally advanced or metastatic non‑squamous NSCLC who progressed after a third‑generation EGFR TKI.
• HARMONi‑3 – evaluate ivonescimab plus chemotherapy versus pembrolizumab plus chemotherapy in patients with first‑line metastatic NSCLC.
• HARMONi‑7 – evaluate ivonescimab monotherapy versus pembrolizumab monotherapy in patients with first‑line metastatic NSCLC and high PD‑L1 expression.

Ivonescimab is investigational and not yet approved in most Summit license territories, including the United States and Europe. It was approved for marketing authorization in China in May 2024 and received Fast Track designation by the FDA for the HARMONi clinical trial setting.

Senior Medical Science Liaison is a field‑based scientific expert who strategically supports Summit Therapeutics’ scientific and business objectives across the product life cycle. MSLs are the primary communicators of Summit science to healthcare professionals (HCPs) within a specific geography and serve as a conduit of information to internal cross‑functional teams.

• Develop, execute, and maintain high‑impact territory plans, including HCP and investigator engagement aligned with therapeutic area objectives.
• Support clinical development and research initiatives across the pipeline, including site evaluation, recruitment, investigator meetings, expert identification, and investigator‑sponsored trials.
• Identify, gain access to, and develop professional relationships with external experts in Immuno‑Oncology within the assigned geography.
• Provide education on disease state, therapeutic landscape, and Summit products across the product lifecycle to HCPs and researchers.
• Participate in and provide insights from relevant scientific meetings and maintain continuous self‑education on market trends and new therapeutic areas.
• Actively participate in team meetings, organizational activities, and country‑driven medical affairs activities (e.g., advisory boards, masterclasses, round tables).
• Create, maintain, and collaborate on relationships with cross‑functional partners to develop and execute account plans that support shared objectives.
• Perform all other duties as assigned.

• Doctoral degree in health sciences (MD, PhD, Pharm
  
  D, or equivalent) required; significant clinical/industry oncology experience may be accepted in lieu of education.
• Minimum 5 + years of solid tumor cancer experience.
• Minimum 5 + years of clinical, scientific/research, or industry experience.
• Minimum 2 + years in a Medical Science Liaison role.
• Prior pharmaceutical industry experience in a relevant scientific discipline strongly preferred.
• MSL must demonstrate past achievements in:
• Understanding, analyzing, and communicating complex scientific concepts.
• Building credible relationships with prominent HCPs.
• Identifying and translating corporate needs into actionable plans.
• Self‑motivation and goal attainment.
• Problem‑solving and analytic skills.
• Critical thinking and independent work.
• Must meet HCIR credentialing requirements to access facilities and organizations in the territory.
• Other requirements:
• Willingness to travel up to 75% of the time.
• Proficiency with MS Office, document management systems, and database tools.
• Attention to detail, accuracy, and confidentiality.
• Clear oral and written communication.
• Excellent organizational skills.
• Ability to multitask, manage conflicting demands, and work in a fast‑paced, collaborative environment.

Base salary range: $200,000 – $235,000 annually. Compensation packages may include bonus, stock, benefits, and other variable components.

New York, United States

Summit does not accept referrals from employment agencies. All agencies must contact Summit’s Talent Acquisition team at  for prior written authorization.