Senior Scientist, Analytical Chemistry; LC-MS

Senior Scientist, Analytical Chemistry (LC-MS)

Regeneron Pharmaceutical's Analytical Chemistry Group, located in Tarrytown, NY, is seeking an energetic Sr. Scientist
. In this exciting role, you will work in a state‑of‑the‑art mass spectrometry lab and provide analytical and biochemical characterization of therapeutic protein drug candidates to support all stages of drug development, from early‑stage candidate selection to late‑stage regulatory submissions. This role will also have opportunities to develop innovative mass spectrometry related technologies to support Regeneron R&D programs in the context of multidisciplinary project teams.

• Design, execute, and optimally communicate analytical characterization of biotherapeutics, including monoclonal and bispecific antibodies, Fc‑fusion proteins, and other modalities (adeno‑associated virus, siRNA, etc.) to support drug development.
• Lead and deliver on characterization activities to elucidate product quality attributes like post‑translational modifications, sequence variants, charge variants, size variants, and host cell proteins.
• Form and maintain inter‑departmental collaborations to solve any potential drug development issues.
• Proactively find opportunities to advance LC‑MS analysis of biotherapeutics by developing technical innovations that will contribute to future developmental needs and/or efficiency gains.
• Document experiments, results, and findings in electronic laboratory notebook (ELN) entries.
• Present results during internal and external meetings.
• Prepare and review regulatory submission documents like IND, comparability, and BLA reports, as well as manuscripts for publication in peer‑reviewed journals.
• Serve as a team representative and provide analytical knowledge and expertise to cross functional teams.

• You are a critical‑thinker and excel at identifying and solving problems.
• You thrive in creative and flexible team environments.
• You are self‑motivated and can lead and coordinate multiple projects in a timely manner.

To be considered you must have a PhD degree in Analytical Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a closely related field. Proficiency in performing cell‑based assays is required for this role, with strong preference given to those with hands‑on experience working with primary cells and associated techniques. Extensive experience with advanced mass spectrometers (Orbitrap, Q‑TOF, Triple Quadrupole, etc.), liquid chromatography, and data processing software (Proteome Discoverer, Skyline, Protein Metrics, Max Quant, etc.)

is desired. To be successful in this role, candidates must be detailed, diligent, highly efficient, and capable of collaborating within a team and with external partners. Excellent written and verbal communication skills are essential to this position.

Salary Range (annually): $ - $

• Associate

• Full‑time

• Research
• Biotechnology

Regeneron offers an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.

The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company’s business.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.