Research Associate, Multiomics and Immune Profiling Lab

Research Associate, Multiomics and Immune Profiling Lab

New York, NY (Onsite)

Biohub is leading the new era of AI-powered biology to cure or prevent disease through its 501c3 medical research organization, with the support of the Chan Zuckerberg Initiative.

The Biohub in New York is an independent nonprofit research institute that brings together three powerhouse universities – Columbia University, The Rockefeller University, and Yale University – into a single collaborative technology and discovery engine. Biohub itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies.

We are guided by our values of scholarly excellence; disruptive innovation; hands‑on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

Our Vision

• We pursue large scientific challenges that cannot be pursued in conventional environments
• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at Biohub facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

Biohub is seeking a skilled and collaborative Research Associate to support the development and operation an Multiomics and Immune Profiling Lab (MIP Lab) at Yale University (in Biohub Yale Annex
). Responsibilities include managing human samples, processing PBMCs, and focusing on immunology, flow cytometry, and cell‑based assays and technologies. The person will implement functional cell‑based and immunological assays, perform cell sorting and flow cytometry analysis in support of large‑scale collaborative projects. This position is ideal for someone who is passionate about immunological technologies and cell‑based assays and thrives in a team‑oriented, high‑throughput environment.

The mission of Biohub—a collaborative effort between CZI, Yale, Columbia, and Rockefeller Universities—is to harness the human immune system for early disease detection and prevention. We are developing cutting‑edge approaches to decode immune cell trafficking and sensing, engineer immune cells, and decipher the disease sensing code of immune cells throughout the body. The MIP Lab will implement and develop cutting‑edge immune monitoring, profiling, and engineering technologies to support the mission of the Biohub and its Annex  selected candidate will join a dynamic and exciting team and this position will allow the candidate to continue to build and expand their laboratory, scientific, and cross‑disciplinary teamwork skills.

• Maintain and operate cell sorter and spectral flow cytometers.
• Manage human samples; coordinate sample processing and experimental workflows with collaborating investigators.
• Design and execute complex spectral flow cytometry experiments, including multi‑parameter panel optimization and data acquisition.
• Set up and optimize in vitro cell stimulation assays and functional immunological readouts.
• Establish and maintain primary cell culture systems and immortalized cell lines for immunological studies.
• Develop and implement standardized protocols for cell‑based assays, including viability assessment, proliferation assays, and cytokine measurements.
• PBMC isolation and processing.
• Perform quality control analysis of flow cytometry and immunological assay data to support experimental troubleshooting.
• Maintain detailed documentation of protocols, experimental conditions, and results
• Work closely with other team members to support large‑scale profiling and human immune monitoring projects.
• Contribute to the training and mentoring of junior team members on cell and flow cytometry techniques.
• Interacts with collaborators/PIs and their lab…