Scientist II, Immunology

Overview

Job Title:
Scientist II
- Immunology

Location: NYC

About Us:

Anvia Therapeutics is a dynamic and innovative biotech company dedicated to developing small molecule inhibitors targeted at treating inflammatory and autoimmune diseases. We foster a collaborative environment where scientific excellence and creativity drive our mission to develop impactful medicines.

Job Summary

We are seeking a highly motivated immunology Scientist to drive hypothesis-driven in vitro immunology research in a fast-paced and innovative drug discovery environment. The successful candidate will design, develop, and execute complex cellular assay systems, including primary human immune cells, patient-derived samples, and disease-relevant cell lines to support immune pharmacology and mechanism-of-action (MoA) studies across inflammatory disease programs such as IBD, rheumatoid arthritis, and dermal inflammation.

Key Responsibilities

• Design and execute hypothesis-driven cellular assays to support immune pharmacology, target validation, and MoA studies.
• Develop, optimize, and validate complex in vitro assay systems using primary immune cells, patient-derived samples, and disease-relevant or engineered cell lines.
• Perform functional immune assays including cell activation, proliferation, cytokine production, signaling, and cytotoxicity, using both primary and cell-line–based systems.
• Contribute to immune pharmacology assessments, including compound potency, pathway modulation, selectivity, and translational relevance.
• Apply a strong mechanistic understanding of immune and inflammatory signaling pathways to guide assay design and data interpretation.
• Utilize flow cytometry, ELISA/MSD/other cytokine/chemokine profiling techniques, protein- and signaling-based assays, and related techniques to generate high-quality, reproducible data.
• Analyze, interpret, and clearly communicate experimental results to project and leadership teams.
• Troubleshoot and refine experimental systems to improve robustness, scalability, and biological relevance.
• Maintain accurate experimental records using electronic laboratory notebooks.
• Collaborate closely with lead discovery, chemistry, translational, and external partners to advance program milestones.
• Stay current with emerging immunology technologies and incorporate innovative methodologies where appropriate.

Required Qualifications

• PhD in Immunology, Biology, Biotechnology, Molecular Biology, or a related field with 2+ years of relevant experience.
• Hands-on experience developing and executing complex cellular assays using primary immune cells, patient-derived samples, and cell line–based systems.
• Experience working with functional immune readouts, including flow cytometry–based phenotyping and signaling assays, and cytokine measurement (ELISA/MSD/other).
• Demonstrated expertise in protein-level analysis of signaling pathways, including Western blotting and related biochemical techniques used to assess pathway activation, inhibition, and mechanism of action.
• Strong understanding of cell signaling pathways relevant to immune and inflammatory biology.
• Proven ability to independently design experiments, troubleshoot assays, and manage multiple priorities.
• Proficiency with data analysis and visualization tools (e.g., Graph Pad Prism, Flow Jo, Excel).
• Excellent written and verbal communication skills.

Preferred Qualifications

• Experience supporting immune pharmacology and MoA characterization in early drug discovery.
• Background in inflammatory or autoimmune disease biology (IBD, RA, dermatology preferred).
• Familiarity with assay validation, quantitative potency assessment and translational biomarker analysis/ identification.
• Experience working in a fast-paced, innovative biotech environment.

Why Join Us?

• Be part of a passionate team making a difference in biotech innovation.
• Collaborative and dynamic work environment.
• Hands-on experience with state-of-the-art technologies.
• Opportunities for professional development and advancement.
• Competitive compensation and benefits.

The salary range for this position is $115,000-$150,000 per year. The actual compensation offered will be based on factors such as…