Senior Scientist– Innate Immunity & In Vitro Modeling

Senior Scientist– Innate Immunity & In Vitro Modeling

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.

To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.

As a Senior Scientist in the Viral Vaccines group, you will spearhead groundbreaking research dissecting the early innate immune mechanisms that shape vaccine efficacy and reactogenicity. You will lead projects to uncover novel immunological mechanisms driving vaccine efficacy, investigate new models to drive vaccine selection, and directly contribute to the discovery of new vaccine targets and the optimization of immunogenic formulations.

• Regularly contribute and influence at the project team level.
• Design and execute experiments to profile innate immune responses to vaccine candidates, driving candidate selection and advancement.
• Develop in vitro and ex vivo assays and models to validate biomarkers predictive of vaccine efficacy and reactogenicity.
• Develop, optimize, and perform flow cytometry and multiplex cytokine assays to support preclinical studies and evaluate new models.
• Supervise junior colleagues in design and execution of experiments.
• Identify, troubleshoot, and optimize relevant assay systems, technologies, and readouts.
• Conduct research leading to publication in peer‑reviewed journals and presentation at internal and external meetings.
• Effectively collaborate with other members of Vaccine Research & Development and supporting partner lines.

Must‑Have

• PhD in Immunology with 0 to 4 years of scientific/technical experience, or Master’s degree with 7 to 10 years of scientific/technical experience.
• Strong background in innate immunity and track record of scientific excellence in immunology.
• Highly skilled with biomarker assay platforms such as ADCC, ADCP, ELISPOT, ELISA, Luminex, MSD.
• Proficiency in multiparametric flow cytometry assays, including immunophenotyping and immune‑based functional assays.
• Expertise in primary cell immune isolation, differentiation, and characterization from murine tissues and human blood.
• Extensive experience in innate immune cell subset isolation and characterization using multicolor flow cytometry.
• Knowledge of trained immunity and systems vaccinology.
• Experience with human organoid vaccine models.
• Ability to perform complex data analysis and strong communication skills.
• Strong time management and organizational skills.

Nice‑to‑Have

• Experience with adjuvant vaccine assay development.
• Experience with coding, including writing R and Python scripts.
• Solid background in vaccine research, innate immunology, infectious diseases, or related fields, and desire to continue in a laboratory‑focused role.

• Work Location Assignment:
  On Premise
• Relocation package available

The annual base salary for this position ranges from $90,900.00 to $. In addition, the position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share‑based long‑term incentive program. Benefits include a 401(k) plan with Pfizer matching contributions, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, medical, prescription drug, dental and vision coverage, and other comprehensive programs.

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.

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