Director​/Senior Director, HEOR Modeling and Evidence Synthesis

Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, agitation associated with dementia due to Alzheimer’s disease, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, as well as multiple novel product candidates addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States.

Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish. For more information, please visit us at  and follow us on Linked In and X.

Axsome Therapeutics is seeking a Director/Senior Director, HEOR Modeling and Evidence Synthesis to serve as the company’s senior technical expert for health economic modeling and comparative evidence generation. Reporting to the Associate Vice President of Health Economics & Evidence Generation Strategy, this hands‑on role will conceptualize, build, validate, interpret, and communicate fit‑for‑purpose models supporting marketed products and pipeline assets across rare and prevalent CNS conditions.

The Director/Senior Director will lead the scientific strategy and execution of cost‑effectiveness, budget impact, disease, and other decision‑analytic models; and lead systematic literature reviews, indirect treatment comparisons, and formal network meta‑analyses. The individual will partner closely with HEOR Product Leads, HEOR Analytics, Medical Strategy, Market Access, Publications, and other cross‑functional colleagues to translate clinical, epidemiologic, economic, and patient‑centered evidence into decision‑ready insights, payer‑relevant materials, and high‑quality scientific publications.

This role is based at Axsome’s HQ in New York City with an on‑site requirement of at least three days per week. We are unable to consider candidates who are looking for fully remote roles.

include, but are not limited to, the following:

• Responsible for end-to-end development of health economic models, from conceptualization and technical specifications through programming, validation, adaptation, reporting, interpretation, and external communication in partnership with HEOR Product Leads and cross‑functional stakeholders.
• Design and develop fit‑for‑purpose models, including cost‑effectiveness and cost‑utility models, cost‑consequence analyses, budget impact models, decision trees, cohort and patient‑level state‑transition models, partitioned‑survival models, discrete‑event simulations, microsimulations, and disease‑progression and natural‑history models, as appropriate.
• Select appropriate modeling approaches reflecting disease characteristics, product maturity, available evidence, stakeholder requirements, and intended use, including both rare and prevalent conditions.
• Develop transparent model structures, assumptions, inputs, parameter distributions, and validation plans; conduct deterministic, probabilistic, scenario, threshold, and structural uncertainty analyses.
• Lead internal and external technical review and validation of models; ensure reproducibility, version control, quality control, complete technical documentation, and adherence to good modeling practices.
• Partner with HEOR Product Leads to prioritize modeling and evidence‑synthesis needs…