Senior Associate Scientist, R&D Chemistry

Senior Associate Scientist, R&D Chemistry

We are currently seeking a synthetic organic chemist for the R&D (Research & Development) Chemistry group. In this position, the candidate will support Regeneron’s small molecule antibody‑conjugate drug discovery capabilities, providing an important link with the company’s existing expertise in biologics and novel genetic medicines. The candidate will enable in‑house laboratory‑based synthetic chemistry activities toward the discovery and generation of novel small‑molecule payloads and linkers for antibody‑drug conjugate therapeutics across research areas of oncology, metabolic disease/obesity, infectious diseases, immunology and inflammation, neuroscience, and ophthalmology.

Cultural fit with the Regeneron chemistry and cross‑functional teams is a priority.

The R&D Chemistry team is composed of synthetic organic, medicinal chemistry, and bioconjugation scientists that work in a highly collaborative environment with other technology, biology, and therapeutic area groups. Successful candidates will have a small‑molecule synthetic organic background and experience with retrosynthetic analysis, synthetic route design, and hands‑on execution of multistep synthetic protocols, including compound isolation and characterization. A firm understanding of modern organic synthesis strategies and techniques and the ability to work independently while deploying them in a fit‑for‑purpose efficient approach to biologically active targets will be the key.

Ability to interpret spectroscopic data in the assignment/confirmation of small‑molecule structures is required. Knowledge of the latest synthetic methods used in antibody‑conjugate linker generation is a plus.

• Perform day‑to‑day laboratory activities as part of the R&D Chemistry group, providing experimental execution of small‑molecule syntheses and associated compound isolation and characterization.
• Troubleshoot, analyze data, interpret experimental results, and propose synthetic approaches to new targets.
• Discuss biological data and new targets within existing projects to address structure‑activity relationship directions.
• Identify new strategies and technologies best suited for synthetic execution of targets of interest.
• Work within the priorities set by the cross‑functional teams and supervisor to ensure successful progression of the group’s technology and pipeline projects.
• Participate in departmental and cross‑functional meetings to contribute expertise and represent the goals of the R&D Chemistry group.
• Interact broadly and collaboratively with other Regeneron groups.

• You are passionate and enthusiastic about the promise of small‑molecule‑based, antibody‑targeted therapeutics and appreciate the challenges of synthetic chemistry and drug design.
• You enjoy developing solutions for synthesis and advancing structure‑activity relationships within medicinal chemistry drug discovery programs.
• You are comfortable working as part of a cross‑functional team.
• You want to be part of a culture that supports growth and development of its people and capabilities to drive forward the Regeneron pipeline.

Have a M.Sc. in synthetic organic chemistry (or related) and familiarity with drug discovery processes and modern methods of synthetic organic and medicinal chemistry.

Bonus experience includes a general understanding of the processes of biological target validation, ADME/PK, PD/efficacy, and how medicinal chemistry contributes to progress in these areas.

A minimum of 5–7 years of industry drug discovery experience with small molecules is required. Familiarity with peptidomimetics or…