Industrial PhD student in Bioinformatics

Industrial PhD student in Bioinformatics

We are announcing a position for a Data-Driven Life Science (DDLS) PhD student in data-driven precision medicine and diagnostics. To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. A doctoral degree corresponds to four years of full-time study.

This is an industry PhD project which is a collaboration between the
Karolinska Institute
,
Sci Life Lab and
Ribocure Pharmaceuticals AB
. The PhD student will be employed by Ribocure Pharmaceuticals AB but admitted to PhD studies at the Karolinska Institute. The studies will primarily take place at the Karolinska Institute and Sci Life Lab  in Stockholm, with frequent research internships at Ribocure Pharmaceuticals AB in Gothenburg.

We offer a creative and inspiring environment full of expertise and curiosity. The Karolinska Institute is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At the Karolinska Institute, we conduct successful medical research and hold the largest range of medical education in Sweden.

As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Tbe Karolinska Institute collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges.

Ribocure Pharmaceuticals AB, based in Gothenburg, is a clinical‑stage biotech company developing innovative siRNA‑based therapies. Our research focuses on areas with high unmet medical need, including cardiovascular, metabolic, liver, and kidney diseases. We have access to a strong and vertically integrated platform in oligonucleotide research, spanning from early discovery to clinical development. Our goal is to turn cutting‑edge science into new medicines for patients.

The PhD project will be embedded in a close collaboration with Ribocure, providing the candidate with valuable exposure to industrial drug development, insight into how academic discoveries are translated into medicines, and experience of working at the interface between fundamental research and therapeutic innovation.

Project title: “RIBO-LINC:
Linking data-driven solutions and RNA innovation for liver and cardiometabolic health”.

An exciting opportunity is available to join a cutting-edge project at the interface of AI, multi-omics, and RNA therapeutics, aiming to transform precision medicine for cardiometabolic and liver diseases. Current therapeutic strategies largely operate at the gene level, overlooking the functional diversity generated by alternative splicing. This project addresses this critical gap by developing data-driven approaches to identify and prioritize isoform-specific therapeutic targets, enabling a new level of precision in RNA-based treatments.

The project will combine large-scale multi-omics integration with advanced machine learning, including artificial neural networks, to predict disease-relevant splice variants across cardiometabolic diseases. By leveraging extensive meta-cohort and perturbation datasets, the work aims to uncover isoform-level regulatory mechanisms and guide the development of next-generation RNA therapeutics with improved specificity and reduced off-target effects. Importantly, computational predictions will be directly linked to experimental evaluation of GalNAc-conjugated RNA therapeutics.

This position offers a unique opportunity to work in a highly interdisciplinary environment, contributing to the development of transformative therapies at the…