Postdoctoral Associate - Disney Lab

Classification Title

Postdoctoral Associate

Qualified applicants should have completed a relevant Ph.D. degree in structural biology, chemical biology, or organic/medicinal chemistry.

Effective immediately, the Disney group in the Department of Chemistry at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology ( (Use the "Apply for this Job" box below). ) is seeking to hire a Postdoctoral Associate in RNA Chemical Biology.

The Disney group is a chemical biology laboratory focused on developing rational approaches to design highly selective therapeutics from only genome sequence. Known for its prolific output and pioneering research culture, the group has furthered advancements in annotating RNA structure from sequence alongside several novel technologies created in-house. The laboratory’s targeting of RNA by small molecules, an ambitious and highly focused enterprise in pursuit of chemical probe and lead medicine development, is summarized in Nature Reviews Drug Discovery ): 169–179.

• Studying disease mediated by RNA repeat expansions that cause genetically defined ALS and dementia:
  Science Translation Medicine (2021) 13:eabd
  5991; doi: 10.1126/scitranslmed.abd
  5991
• Neuron (2014) 83:1043-50; doi: 10.1016/j.neuron.
• Cell Chemical Biology (2019) 26:179-190; doi: 10.1016/j.chembiol.
• Targeted RNA degradation and related technologies: Nature Reviews Drug Discovery ): 169–179; doi: 10.1038/s-8
• Journal of the American Chemical Society (2021) 143:; doi: 10.1021/jacs.
  1c02248
• Science Translation Medicine (2021) 13:eabd
  5991; doi: 10.1126/scitranslmed.abd
  5991
• Proceedings of the National Academy of Sciences USA (2020) 117:; doi: 10.1073/pnas.
• Proceedings of the National Academy of Sciences USA (2019) 116:; doi: 10.1073/pnas.
• Journal of the American Chemical Society (2018) 140:; doi: 10.1021/jacs.
  8b01233
• Nature Chemical Biology (2017) 13:188-193; doi: 10.1038/nchembio.
  225
• Precision targeted therapeutics for difficult-to-treat cancers and other diseases:
  Journal of the American Chemical Society (2019) 141:; doi: 10.1021/jacs.
  8b10558
• Cell Chemical Biology (2018) 25:; doi: 10.1016/j.chembiol.
• Proceedings of the National Academy of Sciences USA (2016) 113:; doi: 10.1073/pnas.
• Proceedings of the National Academy of Sciences USA (2020) 117:; doi: 10.1073/pnas.

The Disney group is highly committed to each individual’s professional development during his or her time in the lab. A high impact research project and training plan to support the achievement of short-term as well as long-term career goals is customized for each student.

Commensurate with experience.

Qualified applicants should have completed a relevant Ph.D. degree in structural biology, chemical biology, or organic/medicinal chemistry.

Preference will be given to candidates with strong skills in RNA biology techniques, molecular biology, and biochemical methods. Previous experience with RNA-seq data analysis, DNA-encoded library design and screening, and structure-based design is also desirable.

Highly motivated candidates possessing a strong academic track‑record, a high‑impact publication list, a team‑player mentality, and an interest in targeting the RNA world are poised for success in the group.

The Disney group employs a broad range of experimental techniques, and thus a wide set of research skills is preferable, and a willingness to learn new methods is essential.

In order to be considered, you must upload your cover letter and resume.

The final candidate will be required to provide official transcript to the hiring department…