Principal Analytical Scientist; Automation

At Regeneron, we use science and innovation to develop life‑changing medicines for people with serious diseases. We are seeking a Principal Analytical Scientist to join our Quality Control team in Rensselaer, NY, supporting our IOPS organization on‑site. In this role, you will shape the future of QC analytical testing by designing, developing, and scaling automated assay workflows across advanced laboratory platforms, while mentoring scientists and fostering a culture of technical growth and innovation.

This position offers the opportunity to contribute to a fast‑growing, science‑driven organization making a meaningful difference to patients worldwide.

Location:

Rensselaer, NY (Tempel Lane)

Work Model:
On‑site

Travel:
Minimal

• Lead the design, implementation, and optimization of automated assay workflows across modern laboratory platforms, applying deep expertise in mass spectrometry, chromatography, bioassay, electrophoresis, and ELISA.
• Mentor and develop junior and mid‑level scientists, building team capability in analytical science and laboratory automation.
• Set priorities, coordinate work, and track progress on analytical and automation initiatives against key milestones.
• Independently design and execute studies to evaluate emerging automation technologies and troubleshoot existing systems with limited supervision.
• Lead complex investigations into automated method performance, supporting verification activities and driving continuous improvement.
• Transfer automated workflows to QC and partner functions by developing training materials, transfer plans, and acceptance criteria.
• Engage cross‑functional collaborators and equipment vendors to evaluate new technologies and assess their fit for QC applications.
• Prepare clear scientific reports, automation procedures, and SOPs; communicate findings, risks, and mitigation strategies to management and cross‑functional teams.

• Bring hands‑on experience programming and optimizing automated liquid handling systems (e.g., Hamilton/Venus, Andrew+/One Lab, or Cellario) and scripting in Python, R, or VBA.
• Apply strong troubleshooting skills across both analytical methods and automated instrumentation to resolve complex technical challenges.
• Make sound, independent decisions and proactively recommend experiments or solutions based on deep expertise in analytical science and automation.
• Lead by example in technical discussions, elevating the team’s capabilities in automation strategy, method development, and process optimization.
• Thrive in a collaborative, fast‑paced environment and can prioritize effectively across multiple responsibilities while adapting to evolving business needs.
• Communicate complex automation concepts clearly to diverse audiences—both in written reports and in cross‑functional settings.
• Proactively share knowledge and take pride in developing others through structured training and mentorship.
• Deliver on commitments safely, with high quality, and in compliance with regulatory expectations.

Standard 1st shift, Monday–Friday, 8:00 a–4:30 p.

• 8+ years of industry experience in analytical development, laboratory automation, and QC method lifecycle management (or equivalent combination of education and experience).
• Demonstrated hands‑on expertise in automated liquid handling platforms and associated software programming.
• Proficiency in scripting languages (Python, R, or VBA) for data analysis, workflow automation, or system integration.
• Deep knowledge of QC analytical techniques including mass spectrometry, chromatography, electrophoresis, bioassay, or ELISA.
• Proven ability to work independently, design scientifically sound studies from broad…