Principal Analytical Scientist; Automation

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Principal Analytical Scientist to join our Quality Control team in Rensselaer, NY, supporting our IOPS organization on-site. In this role, you will shape the future of QC analytical testing by designing, developing, and scaling automated assay workflows across advanced laboratory platforms, while mentoring scientists and fostering a culture of technical growth and innovation.

This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

Location:

Rensselaer, NY (Tempel Lane)

Work Shift:

Monday-Friday 1st shift

• Lead the design, implementation, and optimization of automated assay workflows across modern laboratory platforms, applying deep expertise in mass spectrometry, chromatography, bioassay, electrophoresis, and ELISA.
• Mentor and develop junior and mid-level scientists, building team capability in analytical science and laboratory automation.
• Set priorities, coordinate work, and track progress on analytical and automation initiatives against key milestones.
• Independently design and execute studies to evaluate emerging automation technologies and troubleshoot existing systems with limited supervision.
• Lead complex investigations into automated method performance, supporting verification activities and driving continuous improvement.
• Transfer automated workflows to QC and partner functions by developing training materials, transfer plans, and acceptance criteria.
• Engage cross-functional collaborators and equipment vendors to evaluate new technologies and assess their fit for QC applications.
• Prepare clear scientific reports, automation procedures, and SOPs; communicate findings, risks, and mitigation strategies to management and cross-functional teams.
• Bring hands‑on experience programming and optimizing automated liquid handling systems (e.g., Hamilton/Venus, Andrew+/One Lab, or Cellario) and scripting in Python, R, or VBA.
• Apply strong troubleshooting skills across both analytical methods and automated instrumentation to resolve complex technical challenges.
• Make sound, independent decisions and proactively recommend experiments or solutions based on deep expertise in analytical science and automation.

• 8+ years of industry experience in analytical development, laboratory automation, and QC method lifecycle management (or equivalent combination of education and experience).
• Demonstrated hands‑on expertise in automated liquid handling platforms and associated software programming.
• Proficiency in scripting languages (Python, R, or VBA) for data analysis, workflow automation, or system integration.
• Deep knowledge of QC analytical techniques including mass spectrometry, chromatography, electrophoresis, bioassay, or ELISA.
• Proven ability to work independently, design scientifically sound studies from broad objectives, and drive projects to completion.
• Level will be determined based on qualifications at the time of offer.

• PhD in Chemistry, Biochemistry, Biology, or a related field.
• Previous experience working in a cGMP or cGLP regulated environment.
• Familiarity with Cellario, Venus (Hamilton), or One Lab (Andrew+) automation platforms.
• Experience developing and executing technology transfer plans across QC or partner functions.

Physical Requirements:

Ability to work in a laboratory environment, including standing for extended periods and handling laboratory equipment.

Gowning & Environment:
This role operates in a GMP analytical laboratory. Appropriate gowning and PPE are required in designated areas.

Regeneron is an equal opportunity…