Senior Scientist, Bioanalytical Development

Position:

Senior Scientist, Bioanalytical Development

Location:

Newark, CAJob :

427

# of Openings:

0

Senior Scientist, Bioanalytical Development About UsProtagonist Therapeutics is a biopharmaceutical company built on a proprietary peptide technology platform that has now produced two FDA-approved, first-in-class medicines, generating royalties and milestones from global commercial partnerships with Johnson and Johnson and Takeda Pharmaceutical Company Limited. ICOTYDE (icotrokinra), licensed to Johnson & Johnson company Janssen Biotech, Inc., is the first and only targeted oral peptide that precisely blocks the Interleukin-23 receptor.

ICOTYDE was launched in the U.S. in March 2026 for the treatment of moderate-to-severe plaque psoriasis in adults and pediatric patients 12 years of age or older and is in Phase 3 development for psoriatic arthritis, ulcerative colitis and Crohn's disease. ICOTYDE was jointly discovered by Protagonist and Johnson & Johnson scientists, with Protagonist having primary responsibility for the development of ICOTYDE through Phase 1, and Johnson & Johnson assuming responsibility for further clinical and regulatory development and commercialization.

Protagonist also discovered and led research and development through Phase 3 for MIMRYLO (rusfertide), a first-in-class hepcidin mimetic peptide licensed to Takeda Pharmaceutical Company Limited for worldwide commercialization. MIMRYLO is approved in the U.S. for the treatment of erythrocytosis in adults with PV. The Company also has a number of clinical and preclinical programs based on clinically and commercially validated targets and addressing unmet medical needs, including an oral IL-17 antagonist peptide, anti-obesity dual and triple agonists, an oral hepcidin functional mimetic, and the recently announced IL-4 and amylin discovery programs.

More information on Protagonist, its pipeline drug candidates, and clinical studies can be found on the Company's website at .Position Summary We are seeking a Senior Scientist in the Bioanalytical department. The qualified candidate will be a critical member of the group and work closely with our established team developing and optimizing analytical methods and performing bioanalytical work to screen chemical entities for new drug candidates.

This is an exceptional opportunity to work with a core discovery group within a successful biopharmaceutical company and bring drugs from ideas to the clinic.

We are committed to a thriving in-office culture. This role requires being on-site at our office in Newark, CA 4 days a week.

Responsibilities Operate and maintain analytical instrumentation such as HPLC, mass spectrometer, and other lab equipment

Prepare reagents, calibration standards, QCs and standard curves, and samples for analysis

Perform, optimize, develop, and execute new and existing analytical methods

Perform analytical assays (i.e., ELISA) to support PD and efficacy studies

Work with Bioanalytical team to ensure adequate supplies of consumables and reagents

Possess technical and scientific understanding of bioanalytical assays and experimental design to support the development

Keep excellent experimental records

Effectively communicate results to the Bioanalytical team and cross-functionally

Follow and maintain laboratory safety protocol and health-conscious environment in the workplace.

Required

Skills & Qualifications MS in chemistry, analytical chemistry, biochemistry, bioengineering, or related fields with 5+ years of relevant industry or academic experience or BS with 10+ years of experience.

Previous experience operating and maintaining analytical instrumentation, including HPLC, mass spectrometer, spectrophotometers, and data analysis software

Understanding and experience with the fundamentals of chromatography and analytical separations

Proven ability to follow SOPs and optimize existing methods

Time management and organizational skills with attention to detail

Thrive in a fluid, dynamic, and fast-paced environment

Able to collaborate effectively within multi-disciplinary teams

Effectively communicate results to the Bioanalytical team, across various functional areas, and project team

Pay Range The base pay range for this position at commencement of employment is expected to be between $140,000 and $160,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.

BenefitsA top priority for Protagonist…