Sr. Synthetic Organic Chemists, Ph. D

Wilmington Pharma Tech (WPT) is seeking a highly skilled Senior Synthetic Organic Chemist, PhD to support the design, development, and optimization of synthetic routes for small-molecule APIs and advanced intermediates. This role will play a critical technical leadership position within process development, contributing deep expertise in organic synthesis, route scouting, and scale-up to support kilo-scale and commercial manufacturing programs. The successful candidate will work cross-functionally with Analytical, Manufacturing, and Quality Assurance teams to deliver robust, scalable, and cost-effective chemical processes.

This position reports to the Executive VP of Process Chemistry.

Responsibilities

01

Route Scouting & Design: Design, evaluate, and optimize synthetic routes for APIs and key intermediates, balancing efficiency, safety, scalability, and cost considerations.

Reaction Development: Develop and optimize chemical reactions, including reagent selection, solvent systems, catalysts, and reaction conditions to improve yield, purity, and robustness.

Process Understanding: Apply strong mechanistic understanding and scientific rationale to guide development decisions and troubleshoot complex synthetic challenges.

Literature & IP Review: Conduct thorough literature and patent reviews to identify viable synthetic approaches and ensure freedom to operate.

02

Technology Transfer: Support the transfer of synthetic processes from laboratory scale to pilot plant and manufacturing environments.

Scale-Up Execution: Collaborate with manufacturing teams to scale reactions safely and reproducibly, addressing process risks and variability.

Troubleshooting: Provide hands-on technical support during scale-up, validation, and routine manufacturing to resolve process deviations and performance issues.

Safety & Risk Assessment: Conduct reaction hazard assessments and contribute to safe process design and implementation.

03

Technical Mentorship: Provide scientific guidance and mentorship to junior chemists, fostering technical growth and best practices in the laboratory.

Innovation & Improvement: Identify opportunities to improve synthetic efficiency, sustainability, and process robustness across development programs.

Knowledge Sharing: Contribute to internal knowledge bases, best-practice documents, and continuous improvement initiatives within Process Chemistry.

KEY REQUIREMENTS

Education: PhD in Organic Chemistry or a closely related scientific discipline.

Experience: 0-5+ years of postdoctoral or industry experience in synthetic organic chemistry, process development, or pharmaceutical R&D.

Technical Expertise: Strong hands-on expertise in complex organic synthesis, reaction optimization, and impurity control for small-molecule APIs.

Scale-Up

Experience:

Demonstrated experience supporting scale-up and technology transfer to pilot or commercial manufacturing environments.

Communication: Excellent written and verbal communication skills, with the ability to clearly document work and communicate technical concepts to cross-functional teams and external stakeholders.

For questions, early discussions, or exploratory conversations, please complete the contact formbelow. A member of our team will respond promptly.

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