Laboratory Technician; Neurovascular Pathology

Select how often (in days) to receive an alert:

Requisition

Location:

Newcastle, GB

Contract Type:
Fixed Term

Working Pattern:
Full Time

Posted Date: 1 Sept 2026

Salary: £29,588 per annum

Newcastle University is a great place to work, with excellent benefits . We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.

Closing Date: 15 September 2026

We seek a motivated Technical Assistant to join our team based in the Translational and Clinical Research Institute to support a study on the spatial accumulation of degenerative protein modifications (DPMs) e.g. isoDGR protein motifs in vascular dementia (VaD) and other common dementias, develop blood biomarkers to track DPMs as potential diagnostic tools and assess the efficacy of immunotherapy in two mice models involving stroke and white matter disease that cause vascular cognitive impairment and dementia (VCID).

The position is funded by a UK Chairity (ARUK) for up to 3 years.

The project involves evaluating the spatial distribution and accumulation of isoDGR-proteins in brain and vascular tissues from subjects who developed dementia and relevant controls using immunohistochemistry (IHC) and immunofluorescence (IF) methods. Then identify and test the diagnostic potential of isoDGR biomarkers for patients at high risk of dementia, particularly VCID/post-stroke dementia (PSD) to establish ELISAs to estimate concentrations of isoDGR proteins in postmortem brain tissues and blood (taken in life) samples from the same subjects.

Finally, test the efficacy of anti-isoDGR immunotherapy to promote immune clearance of isoDGR-damaged protein in mouse models of VCID by using immunopathological and fluid immuno-assay methods.

Reporting to the technical manager and principal investigator, the role will require specific technical and practical skills and a well-developed working knowledge of technical practices and procedures, acquired by experience on the job and/or vocational training. The post will work as part of a professional community to provide a technical support service to the project and students by following established working patterns, but there will be a need to resolve most problems without access to senior colleagues.

The role may involve developing skills in a particular specialist area or planning and supervising the work of others.

This is a full time fixed term role for 36 months.

• Assay different analytes from patient samples
• Sample and assay preparations within a laboratory setting
• Use different laboratory methods to analyse tissue or other samples presenting research findings within the group as necessary
• Perform IHC or IF assays on human tissues
• To contribute to the maintenance of SOPs and other laboratory management and quality documents relating to the processing and storage of research samples
• Complete a range of maintenance activities and simple repairs
• Liaise with suppliers and manufacturers to resolve problems and investigate replacement options. Source and negotiate with suppliers for a range of items including specialist parts/equipment
• Advise on equipment capabilities demonstrating how results can be achieved
• By developing local procedures, establish and maintain a safe/compliant working environment
• Oversee compliance tasks ensuring timely completion and maintenance of appropriate records
• Maintain broad and up to date health and safety knowledge providing support/advice to others, assisting with the completion and updating of a wide range of safety paperwork
• Schedule, prioritize and monitor work and performance in line with demands and deadlines
• Hold delegated responsibility from the academic/technical lead for the planning, operation, and supervision of a variety of laboratory spaces
• Work collaboratively with the other areas to ensure efficiency and elimination of duplicated effort
• Be a key contributor to service development, delivery and planning
• Contribute and support change
• Oversee local record keeping, inventory and asset management
• Create, update and implement procedures to…