Clinical Fellow

Salary: £45,591 to £69,976 per annum, pro rata

Newcastle University is a great place to work, with excellent benefits . We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.

Closing Date: 26 October 2026

An exciting opportunity has arisen for a motivated Clinical Fellow to join a nationally recognised renal and complement therapeutics programme.

You will play a central role in a translational research project evaluating the utility of a novel free C5 assay for monitoring terminal complement blockade in patients with complement-mediated atypical haemolytic uraemic syndrome (aHUS) receiving Ravulizumab.

The project aims to determine whether free C5 measurement provides a more accurate assessment of complement inhibition than conventional CH50 testing and to explore its potential role in individualising treatment strategies for patients with aHUS.

The successful candidate will gain experience in rare kidney diseases, complement biology, translational research , and biomarker development while working within a multidisciplinary team of nephrologists, clinical scientists, laboratory specialists, and transplant physicians.

This is a position for a nephrology clinical fellow with previous experience of complement research to undertake a defined research project examining the pharmacodynamics of Ravulizumab in atypical haemolytic uraemic syndrome.

Applicants must be registered nephrologists holding a National Training Number (NTN) and have approval from their relevant Deanery for Out of Programme Research (OOPR). In addition to a medical qualification (e.g. MBBS or equivalent), candidates must possess a scientific degree (e.g. BSc or equivalent). Demonstrable research experience in atypical haemolytic uraemic syndrome (aHUS) is essential, with applicants expected to have a strong understanding of the disease, its pathophysiology, and complement-mediated mechanisms.

The role is part time for 34 hours per week. It is a fixed term post available for the duration of 12 months.

• Identify and recruit eligible patients with complement-mediated aHUS receiving Ravulizumab
• Obtain informed consent and ensure compliance with Good Clinical Practice (GCP) requirements
• Collect detailed clinical, laboratory, and treatment-related data from patient records

The post holder will:

• Coordinate processing and storage of biological samples
• Work closely with laboratory scientists undertaking free C5 measurement
• Facilitate paired analysis of free C5, CH50, AH50, and other complement biomarkers
• Contribute to interpretation of laboratory data and assessment of complement blockade
• Support development of laboratory protocols and standard operating procedures where appropriate

The Clinical Fellow will:

• Maintain accurate and secure study databases
• Perform data collection, validation, and quality assurance activities
• Assist with statistical analysis and interpretation of study findings
• Generate interim reports for study investigators and sponsors

The post holder will:

• Ensure all research activities comply with NHS, University, and regulatory requirements
• Participate in ethics submissions, protocol amendments, and study reporting
• Maintain high standards of data protection and patient confidentiality

The Clinical Fellow will:

• Present findings at departmental, regional, national, and international meetings
• Contribute to the preparation of abstracts, manuscripts, and grant applications
• Participate in journal clubs, research meetings, and educational activities
• Support teaching of medical students, junior doctors, and allied health…