Clinical Pharmacologist

Mantell Associates is partnered with a fast-growing AI-centric biotech organisation, who is searching for a highly motivated and experienced Clinical Pharmacologist to lead translational science initiatives and drive quantitative decision‑making across our preclinical and early clinical programs.

• Lead clinical pharmacology strategy for AI‑driven small molecule and biologic programs, including dose prediction, modelling, simulation, and translational biomarkers
• Design and interpret PK/PD studies to inform candidate selection and optimisation across discovery and early development
• Collaborate with cross‑functional teams (AI/ML scientists, medicinal chemists, toxicologists, clinicians) to integrate clinical pharmacology insights into project decisions
• Develop innovative approaches to leverage AI platforms for predictive pharmacology and optimise clinical trial design
• Provide scientific leadership on regulatory submissions and interactions related to pharmacokinetics, pharmacodynamics and dosing rationale
• Apply quantitative systems pharmacology (QSP) and population modelling to support patient stratification and dose selection
• Mentor and guide junior scientific staff within the translational science function

• Advanced degree (PhD, Pharm
  
  D or equivalent) in Clinical Pharmacology, Pharmacokinetics, Pharmacology or related discipline
• Demonstrated expertise in clinical pharmacology within biotech, pharma, or translational research
• Strong experience in PK/PD modelling, physiologically‑based pharmacokinetics (PBPK), population PK, and quantitative analysis
• Familiarity with AI/ML applications to drug discovery or clinical trial data is highly desirable
• Excellent communicator with ability to articulate complex scientific concepts to multidisciplinary audiences
• Proven track record of delivering translational outcomes that advance drug candidates toward clinical success
• Based in the UK (or eligible to work in the UK), with flexibility for occasional travel

Mantell Associates is a specialist Pharmaceutical and Life Science headhunting firm. For more information on this opportunity, contact us at +44 (0).