PhD Position: Missing Link Aβ Exposure and Inhibitory Synaptic Defects

PhD Position:
Finding the Missing Link between Aβ Exposure and Inhibitory Synaptic Defects

Radboud University is a denominational university originally established in 1923 as the Catholic University of Nijmegen.

Required background Research University Degree

Organizational unit Faculty of Science

Position summary Are you an enthusiastic young scientist with a Master’s degree in a neuroscience‑related field? If so, you have a part to play as a PhD candidate in our research team. Put your ideas to the test at our green campus and push your boundaries in an internationally friendly environment.

The study investigates the formation and plasticity of inhibitory synapses in early Alzheimer’s disease. You will use single‑cell electrophysiology, advanced microscopy techniques and novel biosensors to characterise synaptic defects at inhibitory synapses in cultured brain slices exposed to amyloid β oligomers. You will also monitor molecular and electrophysiological changes to assess the involvement of specific signalling pathways. Your teaching load may be up to 10% of your working time.

• We will give you a temporary employment contract (1.0 FTE) of 1.5 years, after which your performance will be evaluated. If the evaluation is positive, your contract will be extended by 2.5 years (4‑year contract).
• You will receive a starting salary of €3,059 gross per month based on a 38‑hour working week, which will increase to €3,881 in the fourth year.
• You will receive an 8% holiday allowance and an 8,3% end‑of‑year bonus.
• You will receive extra days off. With full‑time employment, you can choose between 30 or 41 days of annual leave instead of the statutory 20.

Work and science require good employment practices. Radboud University’s primary and secondary employment conditions reflect this. You can arrange a flexible working schedule, various leave arrangements, and work‑from‑home options. You may exchange income for extra leave days and receive a reimbursement for your sports membership. Additional benefits include a 34% discount on sports and cultural activities and a good pension plan.

The Wierenga lab is located in the Donders Centre for Neuroscience (DCN) at the Faculty of Science of Radboud University (Nijmegen, Netherlands). You will work with a diverse team of international scientists and use two‑photon microscopy, electrophysiology, and molecular techniques to study the formation and plasticity of inhibitory synapses in organotypic and acute mouse brain slices.

• You are a highly motivated, enthusiastic, critical, creative and team‑oriented young scientist with a particular interest in neuroscience.
• You have a Master's degree in life sciences, biology, biomedical sciences or a related discipline, and an interest in intracellular signalling and optical recording methods.
• Ideally, you have some experience in advanced microscopy and/or electrophysiology in living brain tissue and in programming (in Matlab or a similar environment), or you are willing to learn.
• You take initiative and are eager to learn.
• You can work independently, but you also enjoy interacting within a group.
• You are fluent in English (written and spoken) and have good communication skills.
• You demonstrate integrity and positivity and motivate others to do the same.

You can apply only via the button below. Address your letter of application to Corette Wierenga. The first interviews will take place in the week of 22 June. You will preferably start your employment as soon as possible.