Senior Director, Commercial Accounting

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA;

IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

We are seeking a Senior Director, Commercial Accounting to lead the establishment and execution of commercial accounting operations as we prepare to launch our first product. This role will be instrumental in building scalable accounting processes and the internal control framework for revenue recognition, inventory and cost of goods sold, third-party logistics (3PL) accounting, and gross-to-net considerations while partnering closely with Commercial, Supply Chain, and Finance leadership.

The ideal candidate brings hands-on experience supporting product launches in biotech or life sciences, thrives in a fast-paced, pre-commercial or early-commercial environment, and can balance technical accounting expertise with cross-functional collaboration.

• Own and implement ASC 606 revenue recognition policies, procedures, and control activities for product sales.
• Manage the development of a model and oversee accounting processes for gross-to-net reserves (e.g., chargebacks, rebates, returns, Medicaid/Medicare, and other government and commercial programs, as applicable).
• Oversee accounting for the outsourced order-to-cash process, ensuring accurate billing, revenue cut-off, cash application, and reconciliations.
• Prepare and maintain technical accounting memos, internal control narratives, and process documentation to support internal and external audits.
• Collaborate with FP&A, Commercial, Market Access, Supply Chain, Legal, and IT teams to align accounting, forecasting, and operational execution.
• Provide accounting guidance on new commercial initiatives, pricing strategies, and distribution models in a SOX-controlled environment.
• Lead and develop commercial accounting staff and/or external consultants, as appropriate for company size.
• Prepare SEC reporting, audit committee materials, and internal management reporting related to commercial activities.
• Serve as a primary point of contact for external auditors for commercial accounting functions, including walkthroughs, control testing, and issue remediation.

• Own accounting for worldwide commercial and clinical inventory, including costing, overhead rate planning and application, variances, and inventory cost and quantity roll-forwards .
• Direct the review of monthly manufacturing accruals, partner with cross-functional teams to ensure an accurate and timely financial close, and drive process improvements across the accrual close cycle.
• Establish SOX-compliant controls over inventory valuation, reserves, obsolescence, excess inventory, and physical counts.
• Ensure reconciliation and completeness controls between operational systems, 3PL reports, and the general ledger.
• Provide guidance for ERP and 3PL system implementations, including design, testing, internal controls and audit readiness.

• Bachelor’s degree in Accounting or Finance ; CPA preferred.
• 10+ years of progressive accounting experience, including experience in a public…