Senior Research Associate, Analytical Development

Syst Immune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). Syst Immune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. Syst Immune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development.

We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

As a Senior Research Associate in Analytical Development, the incumbent will be a hands-on contributor to the characterization of antibody-based therapeutics. The Senior RA will execute, troubleshoot, and help optimize analytical methods for early- to mid-stage development, with a focus on UPLC, CE, and binding assays. This is a lab-centered role ideal for an experienced BS/MS-level scientist who is rigorous at the bench, thrives in a dynamic, high-throughput setting, and wants to grow into method development and ownership of analytical workflows.

This is an onsite position in Bothell, WA.

• Independently execute analytical methods using UPLC (SEC, IEX, RP), CE (CE-SDS, cIEF), and binding assays (ELISA, BLI) to support antibody characterization, with a high standard of accuracy and reproducibility.
• Support method optimization and qualification activities under the guidance of senior scientists, and contribute to the development of new methods as needs arise.
• Generate data for cell line development, process development, formulation screening, comparability, and stability studies, and manage sample tracking and testing schedules.
• Process, analyze, and summarize data; perform first-pass interpretation and flag unexpected results or trends to project scientists in a timely manner.
• Maintain accurate, complete, and timely documentation in electronic lab notebooks and data systems in line with good documentation practices.
• Perform routine instrument maintenance, calibration checks, and basic troubleshooting for UPLC, CE, plate readers, and BLI instruments; coordinate service and preventive maintenance.
• Prepare reagents, buffers, reference standards, and critical materials; manage inventory and ordering for the analytical lab.
• Draft method protocols, data summaries, and sections of technical reports for review by senior scientists.
• Collaborate with upstream, downstream, and formulation team members in an integrated CMC environment.
• Contribute to building the analytical lab infrastructure as the company scales, including evaluating new consumables, templates, and workflows.

• BS with 5+ years or MS with 3+ years of relevant industry experience (biotech/pharma) in biologics analytical development or a closely related laboratory function.
• Strong hands-on proficiency with HPLC/UPLC (SEC, IEX, or RP) and/or CE (CE-SDS, cIEF) for therapeutic proteins, including routine troubleshooting.
• Hands-on experience with antibody binding assays (e.g., ELISA, SPR, or BLI).
• Working knowledge of antibody structure, common post-translational modifications, and critical quality attributes (CQAs).
• Demonstrated attention to detail, strong organizational skills, and the ability to manage multiple studies in parallel with shifting priorities.
• Good written and verbal communication skills and a track record of effective teamwork.
• Comfortable working in a fast-paced, evolving environment and willing to take on new responsibilities.

• Prior experience in a GMP…