Principal Scientist II, Analytical Platform Sciences and Characterization, tLNP

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, Facebook, Instagram, X and You Tube.

The Analytical Development group within the Targeted LNP (tLNP) CMC Team at Abb Vie is dedicated to advancing state-of-the-art analytical capabilities for mRNA-lipid nanoparticle therapeutics. Our team provides critical support across drug substance (DS) and drug product (DP) manufacturing, drug product formulation, and the development and implementation of robust analytical methodologies to ensure the quality and integrity of tLNP genetic medicines.

We leverage advanced biophysical, separations, and mass spectrometry techniques to deeply characterize intact LNP particles. We foster close collaborations with cross-functional colleagues in CMC, drug product formulation, and external partners, and are currently growing a world-class team of scientists who will be instrumental in building and deploying the analytical toolbox necessary to deliver high-quality, innovative tLNP medicines to patients.

The Analytical Research & Development group within Targeted Lipid Nanoparticle (tLNP) CMC Team is responsible for building the scientific capabilities that will enable the next generation of genetic medicines. Our team advances innovative analytical approaches that deepen mechanistic understanding of tLNP systems, accelerate development decisions, and create differentiated platform capabilities across Abb Vie's expanding nucleic acid therapeutic portfolio.

We are seeking an exceptional scientific leader to serve as Principal Scientist II/Associate Director of Analytical Platform Sciences & Characterization, leading a multidisciplinary team responsible for advanced characterization, platform science, mechanistic understanding, emerging analytical technologies, and analytical innovation. This individual will drive the development and application of next-generation analytical capabilities spanning particle characterization, structure-function understanding, mass spectrometry, advanced biophysical characterization, data analytics, and other enabling technologies critical to the advancement of tLNP therapeutics.

The successful candidate will partner closely with tLNP Drug Product Development, tLNP Process Development, Discovery, Quality, Regulatory Affairs, and cross-functional CMC teams to convert analytical observations into actionable scientific insights. In addition to serving as a recognized scientific expert, the individual will lead and develop scientists, establish strategic capability roadmaps, foster external scientific collaborations, and help shape the future direction of analytical science within Abb Vie's tLNP CMC organization.

This position represents a unique opportunity to build and lead a growing scientific organization at the intersection of analytical chemistry, nanomedicine, biologics characterization, and genetic medicine development. Beyond technical excellence, the role requires strong organizational leadership, talent development, strategic thinking, and the ability to influence scientific direction across multiple programs and platforms. The selected candidate will report directly to the Director of tLNP Analytical R&D and will play a key role in developing the scientific capabilities, organizational strength, and leadership pipeline needed to support Abb Vie's long-term ambitions in genetic medicines.

Establish and execute the scientific strategy for the Analytical Platform Sciences & Characterization organization, advancing mechanistic understanding of tLNP systems and enabling improved development decisions.

Drive the development and application of advanced analytical technologies and characterization approaches to support Abb Vie's genetic medicines portfolio.

Identify emerging scientific trends, technologies, and opportunities and translate them into differentiated analytical capabilities and platform advantages.

Lead, mentor, and develop a multidisciplinary team of…